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Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells

Brickute, Diana; Chen, Cen; Braga, Marta; Barnes, Chris; Wang, Ning; Allott, Louis; Aboagye, Eric O.

Authors

Diana Brickute

Cen Chen

Marta Braga

Chris Barnes

Ning Wang

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Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics

Eric O. Aboagye



Abstract

Promoting a senescent phenotype to suppress tumour progression may present an alternative strategy for treating cancer and encourages the development of positron emission tomography (PET) imaging biomarkers for assessing response to treatment. The accumulation of lipofuscin deposits in senescent cells is visualised using the pathology stain Sudan Black B (SBB) which is an emerging biomarker of senescence. We describe the design, synthesis and evaluation of [18F]fluoroethyltriazole-SBB ([18F]FET-SBB), a fluorine-18 radiolabelled derivative of SBB. The in vitro uptake of [18F]FET-SBB in a senescent cell line corelated with lipofuscin deposits; in vivo PET imaging and metabolite analysis confirm a favourable pharmacokinetic and metabolic profile for further studies of in vivo models of senescence.

Citation

Brickute, D., Chen, C., Braga, M., Barnes, C., Wang, N., Allott, L., & Aboagye, E. O. (2022). Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells. RSC advances, 12(40), 26372-26381. https://doi.org/10.1039/d2ra04535d

Journal Article Type Article
Acceptance Date Sep 6, 2022
Online Publication Date Sep 15, 2022
Publication Date 2022
Deposit Date Oct 15, 2022
Publicly Available Date Oct 17, 2022
Journal RSC Advances
Print ISSN 2046-2069
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 12
Issue 40
Pages 26372-26381
DOI https://doi.org/10.1039/d2ra04535d
Keywords General Chemical Engineering; General Chemistry
Public URL https://hull-repository.worktribe.com/output/4095209

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http://creativecommons.org/licenses/by/3.0

Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Creative Commons Licence: Attribution License. See: https://creativecommons.org/licenses/by/3.0/





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