All Outputs (83)

A paper-based analytical device for the on-site multiplexed monitoring of soil nutrients extracted with a cafetière (2024)
Journal Article
Giménez-Gómez, P., Priem, N., Richardson, S., & Pamme, N. (2025). A paper-based analytical device for the on-site multiplexed monitoring of soil nutrients extracted with a cafetière. Sensors and actuators. B, Chemical, 424, Article 136881. https://doi.org/10.1016/j.snb.2024.136881

Sustainable agricultural production has the aim to maximise the yield and quality of harvests. For that, farmers need to monitor nutrient levels within soils to apply fertilizers accordingly and to prevent land degradation and soil exhaustion. Curren... Read More about A paper-based analytical device for the on-site multiplexed monitoring of soil nutrients extracted with a cafetière.

Gendered farmer perceptions towards soil nutrition and willingness to pay for a cafetière-style filter system for in-situ soil testing: evidence from Central Kenya (2024)
Journal Article
Kamau, P., Ndirangu, I., Richardson, S., Pamme, N., & Gitaka, J. (2024). Gendered farmer perceptions towards soil nutrition and willingness to pay for a cafetière-style filter system for in-situ soil testing: evidence from Central Kenya. Heliyon, 10(18), Article e37568. https://doi.org/10.1016/j.heliyon.2024.e37568

Soil nutrition is a key pillar in agricultural productivity. However, point-of-need testing for soil nutrition is not readily available in resource-limited settings such as Kenya. We set out to study the perceived need for soil testing among farmers... Read More about Gendered farmer perceptions towards soil nutrition and willingness to pay for a cafetière-style filter system for in-situ soil testing: evidence from Central Kenya.

Paper microfluidic sensors towards on-site environmental analysis of soil nutrients (2024)
Thesis
Al Hinai, S. Paper microfluidic sensors towards on-site environmental analysis of soil nutrients. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4617797

The increase in the world population leads to an increase in the need for production of crops. To optimise crop production fertilizer application needs to be managed by the farmer, consequently, regular information about the chemistry of the soil is... Read More about Paper microfluidic sensors towards on-site environmental analysis of soil nutrients.

Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products (2024)
Thesis
Doyle, B. Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4587910

Upon entering the body, any given xenobiotic can undergo metabolism which facilitates its excretion from the body. When metabolised, a compound typically has the same effects of the initial drug/nutraceutical, however this is not always the case and... Read More about Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products.

Development and validation of spectrophotometric method and paper-based microfluidic devices for the quantitative determination of Amoxicillin in pure form and pharmaceutical formulations (2024)
Journal Article
Oday, J., Hadi, H., Hashim, P., Richardson, S., Iles, A., & Pamme, N. (2024). Development and validation of spectrophotometric method and paper-based microfluidic devices for the quantitative determination of Amoxicillin in pure form and pharmaceutical formulations. Heliyon, 10(3), Article e24968. https://doi.org/10.1016/j.heliyon.2024.e24968

There is a growing need for easy-to-use, low cost and portable quantitative assays to determine active pharmaceutical ingredients in the pharmaceutical industry. Here, we developed a batch spectrophotometric method and a method employing a paper-base... Read More about Development and validation of spectrophotometric method and paper-based microfluidic devices for the quantitative determination of Amoxicillin in pure form and pharmaceutical formulations.

Development of analytical workflows for measurement of metal pollution in freshwater with citizen scientists (2023)
Thesis
Sari, M. Development of analytical workflows for measurement of metal pollution in freshwater with citizen scientists. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4459145

The emergence of heavy metals, such as nickel (Ni2+) and zinc (Zn2+), as freshwater contaminant poses an environmental and public health risk. However, the current monitoring process lacks robustness and the spatiotemporal range, impeded by relativel... Read More about Development of analytical workflows for measurement of metal pollution in freshwater with citizen scientists.

Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites (2023)
Journal Article
Doyle, B., Madden, L. A., Pamme, N., & Jones, H. (2023). Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites. RSC advances, 13(40), 27696-27704. https://doi.org/10.1039/d3ra03742h

The study of naturally circulating drug metabolites has been a focus of interest, since these metabolites may have different therapeutic and toxicological effects compared to the parent drug. The synthesis of metabolites outside of the human body is... Read More about Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites.

A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection (2022)
Journal Article
Ngamsom, B., Iles, A., Kamita, M., Kimani, R., Wakaba, P., Rodriguez-Mateos, P., Mungai, M., Dyer, C. E., Walter, C., Gitaka, J., & Pamme, N. (2022). A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection. Talanta Open, 6, Article 100166. https://doi.org/10.1016/j.talo.2022.100166

In response to the ongoing coronavirus disease 2019 (COVID-19) pandemic and disparities of vaccination coverage in low-and middle-income countries, it is vital to adopt a widespread testing and screening programme, combined with contact tracing, to m... Read More about A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection.

Development of a skin-on-a-chip platform for the study of wound healing (2022)
Thesis
Talar, K. Development of a skin-on-a-chip platform for the study of wound healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4508234

Wound healing abnormalities and non-healing chronic wounds are a major clinical problem, primarily affecting diabetic and elderly patients. Wound management associated costs resulted in a £5.3 billion financial burden to the NHS between 2012 and 2013... Read More about Development of a skin-on-a-chip platform for the study of wound healing.

Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device (2021)
Journal Article
Richardson, S., Iles, A., Rotchell, J. M., Charlson, T., Hanson, A., Lorch, M., & Pamme, N. (2021). Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device. PLoS ONE, 16(12), Article e0260102. https://doi.org/10.1371/journal.pone.0260102

Contamination of waterways is of increasing concern, with recent studies demonstrating elevated levels of antibiotics, antidepressants, household, agricultural and industrial chemicals in freshwater systems. Thus, there is a growing demand for method... Read More about Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.

Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens (2021)
Journal Article
van Belkum, A., Almeida, C., Bardiaux, B., Barrass, S. V., Butcher, S. J., Çaykara, T., …Linke, D. (2021). Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens. Diagnostics, 11(7), Article 1259. https://doi.org/10.3390/diagnostics11071259

Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where... Read More about Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens.

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings (2021)
Journal Article
Rodriguez-Mateos, P., Ngamsom, B., Walter, C., Dyer, C. E., Gitaka, J., Iles, A., & Pamme, N. (2021). A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings. Analytica Chimica Acta, 1177, Article 338758. https://doi.org/10.1016/j.aca.2021.338758

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the unprecedented global pandemic of coronavirus disease-2019 (COVID-19). Efforts are needed to develop rapid and accurate diagnostic tools for extensive testing, allowing for ef... Read More about A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings.

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels (2021)
Journal Article
Rodriguez-Mateos, P., Ngamsom, B., Dyer, C. E., Iles, A., & Pamme, N. (in press). Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels. ELECTROPHORESIS, https://doi.org/10.1002/elps.202100083

Early detection of pathogenic microorganisms is pivotal to diagnosis and prevention of health and safety crises. Standard methods for pathogen detection often rely on lengthy culturing procedures, confirmed by biochemical assays, leading to >24 h for... Read More about Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels.

Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices (2021)
Journal Article
Christensen, M. G., Cawthorne, C., Dyer, C. E., Greenman, J., & Pamme, N. (2021). Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices. Microfluidics and Nanofluidics, 25(4), Article 35. https://doi.org/10.1007/s10404-021-02434-x

Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products. Howeve... Read More about Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices.

Focusing and delivery of laser radiation for nano- and microfabrication (2020)
Thesis
Al-Jarwany, Q. A. (2020). Focusing and delivery of laser radiation for nano- and microfabrication. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223093

The recent advances in nanotechnology and nanofabrication motivate the drive to achieve a tighter focusing of light; this requires a high numerical aperture (NA) optical system. The need for high optical resolution has led scientists to discover the... Read More about Focusing and delivery of laser radiation for nano- and microfabrication.

Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs) (2020)
Journal Article
Abdulsattar, J. O., Hadi, H., Richardson, S., Iles, A., & Pamme, N. (2020). Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs). Analytica Chimica Acta, 1136, 196-204. https://doi.org/10.1016/j.aca.2020.09.045

There is growing demand for simple to operate, sensitive, on-site quantitative assays to investigate concentrations of drug molecules in pharmaceutical preparations for quality assurance. Here, we report on the development of two colorimetric analysi... Read More about Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs).

Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk (2020)
Journal Article
Khan, Q. M., Asif, M., Awan, F. R., Khan, Q. . M., Ngamsom, B., & Pamme, N. (2020). Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk. Analyst, 145(22), 7320-7329. https://doi.org/10.1039/d0an01075h

Animal derived milk which is an important part of human diet due to its high nutritional value not only supports humans but also presents a growth environment for pathogenic bacteria. Milk may become contaminated with bacteria through udder infection... Read More about Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk.

Microfluidic-Based Electrochemical Immunosensing of Ferritin (2020)
Journal Article
Garg, M., Christensen, M. G., Iles, A., Sharma, A. L., Singh, S., & Pamme, N. (2020). Microfluidic-Based Electrochemical Immunosensing of Ferritin. Biosensors, 10(8), Article 91. https://doi.org/10.3390/bios10080091

Ferritin is a clinically important biomarker which reflects the state of iron in the body and is directly involved with anemia. Current methods available for ferritin estimation are generally not portable or they do not provide a fast response. To co... Read More about Microfluidic-Based Electrochemical Immunosensing of Ferritin.

On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers (2020)
Journal Article
Patinglag, L., Esfahani, M. M. N., Ragunathan, K., He, P., Brown, N. J., Archibald, S. J., Pamme, N., & Tarn, M. D. (2020). On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers. Analyst, 145(14), 4920-4930. https://doi.org/10.1039/c9an01881f

The miniaturisation of positron emission tomography (PET) radiotracer production is facilitating a move towards a dose-on-demand strategy that would enable a stratified approach to patient diagnostics, but while the on-chip synthesis steps have been... Read More about On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers.