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Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses (2018)
Journal Article
Terrazzini, N., Mantegani, P., Kern, F., Fortis, C., Mondino, A., & Caserta, S. (2018). Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 217(12), 1997-2007. doi:10.1093/infdis/jiy096

© 2018 The Author(s). Background Interleukin (IL)-7 promotes the generation, expansion, and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-r... Read More

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs (2018)
Journal Article
Caserta, S., Mengozzi, M., Kern, F., Newbury, S. F., Ghezzi, P., & Llewelyn, M. J. (2018). Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs. Frontiers in immunology, 8, doi:10.3389/fimmu.2017.01977

The systemic inflammatory response syndrome (SIRS) is a potentially lethal response triggered by diverse forms of tissue injury and infection. When systemic inflammation is triggered by infection, the term sepsis is used. Understanding how inflammati... Read More

Heterogeneity of phenotype and function reflects the multistage development of t follicular helper cells (2017)
Journal Article
Trüb, M., Barr, T. A., Morrison, V. L., Brown, S., Caserta, S., Rixon, J., …Gray, D. (2017). Heterogeneity of phenotype and function reflects the multistage development of t follicular helper cells. Frontiers in immunology, 8(APR), (489). doi:10.3389/fimmu.2017.00489. ISSN 1664-3224

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1 hi Tfh are important in the GC response, the function of the PD1 lo Tfh-like subset is unknown. We show that... Read More

A new perspective of the structural complexity of HCMV-specific T-cell responses (2016)
Journal Article
Sylwester, A., Nambiar, K. Z., Caserta, S., Klenerman, P., Picker, L. J., & Kern, F. (2016). A new perspective of the structural complexity of HCMV-specific T-cell responses. Mechanisms of ageing and development, 158, (14-22). doi:10.1016/j.mad.2016.03.002. ISSN 0047-6374

© 2016 The Authors Background In studies exploring the effects of HCMV infection on immune system aging (‘immunosenescence’), after organ transplantation or in other settings, HCMV-specific T-cell responses are often assessed with respect to purporte... Read More

Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS) (2016)
Journal Article
Caserta, S., Kern, F., Cohen, J., Drage, S., Newbury, S. F., & Llewelyn, M. J. (2016). Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS). Scientific reports, 6(1), doi:10.1038/srep28006. ISSN 2045-2322

Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be det... Read More

Induction of human regulatory T cells with bacterial superantigens (2015)
Book Chapter
Caserta, S., Taylor, A. L., Terrazzini, N., & Llewelyn, M. J. (2016). Induction of human regulatory T cells with bacterial superantigens. In Superantigens; Methods in Molecular Biology, 181-206. doi:10.1007/978-1-4939-3344-0_16

© Springer Science+Business Media New York 2016. Regulatory T cells (Tregs) that suppress the activation of immune effector cells limit immunopathology and are fast emerging as therapeutic targets for autoimmune and cancer disease. Tools enabling Tre... Read More

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens (2012)
Journal Article
Caserta, S., Borger, J. G., & Zamoyska, R. (2012). Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical reviews in immunology, 32(2), 97-126. doi:10.1615/critrevimmunol.v32.i2.10

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolyti... Read More

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells (2012)
Journal Article
Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A. S., …Zamoyska, R. (2012). Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PloS one, 7(4), e35466. doi:10.1371/journal.pone.0035466

Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibito... Read More

Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens (2010)
Journal Article
Caserta, S., Kleczkowska, J., Mondino, A., & Zamoyska, R. (2010). Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens. Journal of Immunology, 185(11), 6545-6554. doi:10.4049/jimmunol.1001867

The effect of TCR signals on the differentiation of memory T cells is poorly defined. Conventional wisdom suggests that high-avidity interactions are best for the selection of vaccine Ag candidates or T cell specificities for adoptive T cell therapy... Read More

IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells (2009)
Journal Article
Caserta, S., Alessi, P., Basso, V., & Mondino, A. (2010). IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells. European journal of immunology, 40(2), 470-479. doi:10.1002/eji.200939801

It is well established that tumours hinder both natural and vaccine-induced tumourspecific CD4 + T-cell responses. Adoptive T-cell therapy has the potential to circumvent functional tolerance and enhance anti-tumour protective responses. While proto... Read More

Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses (2008)
Journal Article
Caserta, S., Alessi, P., Guarnerio, J., Basso, V., & Mondino, A. (2008). Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses. Cancer Research, 68(8), 3010-3018. doi:10.1158/0008-5472.can-07-5796

CD4 + helper T cells are critical for protective immune responses and yet suboptimally primed in response to tumors. Cell-based vaccination strategies are under evaluation in clinical trials but limited by the need to derive antigenpresenting cells... Read More

Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination (2007)
Journal Article
Zimmermann, V. S., Casati, A., Schiering, C., Caserta, S., Hess Michelini, R., Basso, V., & Mondino, A. (2007). Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination. Journal of Immunology, 179(5), 2899-2909. doi:10.4049/jimmunol.179.5.2899

Dendritic cells loaded with tumor-derived peptides induce protective CTL responses and are under evaluation in clinical trails. We report in this study that prophylactic administration of dendritic cells loaded with a MHC class II-restricted peptide... Read More

Memories are made of this: synergy of T cell receptor and cytokine signals in CD4+ central memory cell survival (2007)
Journal Article
Caserta, S., & Zamoyska, R. (2007). Memories are made of this: synergy of T cell receptor and cytokine signals in CD4+ central memory cell survival. Trends in immunology, 28(6), 245-248. doi:10.1016/j.it.2007.04.006

The ability of the immune system to 'remember' a previous encounter with antigen is the hallmark of the adaptive immune response. The signals required for CD4 + memory T cell survival are not well understood, and a recent paper lends new biochemical... Read More

Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk (2005)
Journal Article
Benigni, F., Zimmermann, V. S., Hugues, S., Caserta, S., Basso, V., Rivino, L., …Mondino, A. (2005). Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk. Journal of Immunology, 175(2), 739-748. doi:10.4049/jimmunol.175.2.739

Technical difficulties in tracking endogenous CD4 T lymphocytes have limited the characterization of tumor-specific CD4 T cell responses. Using fluorescent MHC class II/peptide multimers, we defined the fate of endogenous Leishmania receptor for acti... Read More