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Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods (2016)
Journal Article
He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak aci... Read More about Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods.

Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals (2016)
Journal Article
Taggart, M. P., Tarn, M. D., Esfahani, M. M. N., Schofield, D. M., Brown, N. J., Archibald, S. J., Deakin, T., Pamme, N., & Thompson, L. F. (2016). Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals. Lab on a chip, 16(9), 1605-1616. https://doi.org/10.1039/c6lc00099a

The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insuf... Read More about Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals.

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers (2016)
Journal Article
Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O’Shea, V., Pimlott, S. L., Pamme, N., & Archibald, S. J. (2016). Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(45), 7221-7224. https://doi.org/10.1039/c6cc00660d

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-no... Read More about Positron detection in silica monoliths for miniaturised quality control of PET radiotracers.

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes (2016)
Journal Article
Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), 4977-4987. https://doi.org/10.1039/c6ce00209a

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure d... Read More about Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes.

Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry (2016)
Journal Article
Abdulwahaab, B. H., Burke, B. P., Domarkas, J., Silversides, J. D., Prior, T. J., & Archibald, S. J. (2016). Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry. Journal of Organic Chemistry, 81(3), 890-898. https://doi.org/10.1021/acs.joc.5b02464

Glyoxal-bridged bisaminal tetraazamacrocyclic derivatives of 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) can be N-functionalized to incorporate coordinating groups or for conjugation to biomolecules. Herein,... Read More about Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry.

Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin (2015)
Journal Article
Entract, G. M., Bryden, F., Domarkas, J., Savoie, H., Allott, L., Archibald, S. J., Cawthorne, C., & Boyle, R. W. (2015). Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin. Molecular pharmaceutics, 12(12), 4414-4423. https://doi.org/10.1021/acs.molpharmaceut.5b00606

Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging efficacy of positron emission tom... Read More about Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin.

Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate (2015)
Journal Article
Funwie, N. L., Cain, A. N., Fanning, B. Z., Hageman, S. A., Mullens, M., Roberts, T. K., Turner, D. J., Valdez, C. N., Vaughan, R. W., Ermias, H. G., Silversides, J. D., Archibald, S. J., Hubin, T. J., & Prior, T. J. (2015). Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate. Acta Crystallographica Section E: Crystallographic Communications, 71(9), 1073-1076. https://doi.org/10.1107/S2056989015015340

The title compound, [FeCl₂(C₁₄H₃₀N₄)]PF₆, contains Fe³⁺ coordinated by the four nitro­gen atoms of an ethyl­ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa­hedral environment. In contrast to other similar compound... Read More about Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate.

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions (2015)
Journal Article
Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., Domarkas, J., Lorch, M., Pickles, M., Gibbs, P., Cawthorne, C., & Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describ... Read More about Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions.

Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control (2015)
Journal Article
Archibald, S., Pamme, N., Brown, N., & Tarn, M. (2015). Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control. Journal of nuclear medicine, 56(Supplement 3), Article 167

Objectives Dose-on-demand radiotracer production, whereby a single dose is generated using a compact synthesis unit with radioisotope from a mini-cyclotron or external supply is an interesting prospect for widening the availabilty of radiotracers. We... Read More about Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control.

Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane (2015)
Journal Article
Matz, D. L., Jones, D. G., Roewe, K. D., Gorbet, M.-J., Zhang, Z., Chen, Z., Prior, T. J., Archibald, S. J., Yin, G., & Hubin, T. J. (2015). Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane. Dalton Transactions : an international journal of inorganic chemistry, 44(27), 12210-12224. https://doi.org/10.1039/c5dt00742a

© The Royal Society of Chemistry 2015. Synthetic details for 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.5.2]pentadecane, the dimethyl ethylene cross-bridged homocyclen ligand are presented for the first time. Its novel Mn 2+ , Fe 2+ , Mn 3+ , and Fe 3+... Read More about Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane.

Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water (2014)
Journal Article
He, P., Haswell, S. J., Pamme, N., & Archibald, S. J. (2014). Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water. Applied radiation and isotopes : including data, instrumentation, and methods for use in agriculture, industry, and medicine, 91, 64-70. https://doi.org/10.1016/j.apradiso.2014.04.021

Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [ 18 F]fluorodeoxygluco... Read More about Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water.

How does iron interact with sporopollenin exine capsules? An X-ray absorption study including microfocus XANES and XRF imaging (2014)
Journal Article
Archibald, S. J., Atkin, S. L., Bras, W., Diego-Taboada, A., Mackenzie, G., Mosselmans, J. F. W., Nikitenko, S., Quinn, P. D., Thomas, M. F., & Young, N. A. (2014). How does iron interact with sporopollenin exine capsules? An X-ray absorption study including microfocus XANES and XRF imaging. Journal of Materials Chemistry B, 2(8), 945-959. https://doi.org/10.1039/c3tb21523g

Sporopollenin exine capsules (SECs) derived from plant spores and pollen grains have been proposed as adsorption, remediation and drug delivery agents. Despite many studies there is scant structural data available. This X-ray absorption investigation... Read More about How does iron interact with sporopollenin exine capsules? An X-ray absorption study including microfocus XANES and XRF imaging.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles (2012)
Journal Article
Smith, R., Huskens, D., Daelemans, D., Mewis, R. E., Garcia, C. D., Cain, A. N., Freeman, T. N. C., Pannecouque, C., Clercq, E. D., Schols, D., Hubin, T. J., & Archibald, S. J. (2012). CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles. Dalton Transactions : an international journal of inorganic chemistry, 41(37), 11369-11377. https://doi.org/10.1039/c2dt31137b

Tetraazamacrocyclic complexes of transition metals provide useful units for incorporating multiple coordination interactions into a single protein binding molecule. They can be designed with available sites for protein interactions via donor atom-con... Read More about CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes (2011)
Journal Article
Silversides, J. D., Smith, R., & Archibald, S. J. (2011). Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes. Dalton Transactions : an international journal of inorganic chemistry, 40(23), 6289-6297. https://doi.org/10.1039/c0dt01395a

The synthesis of chelators that form high stability complexes with copper(II) isotopes and do not suffer from transchelation in vivo has been a goal for many chemists. Such chelators will facilitate the exploitation of the Cu-64 isotope (t(1/2) = 12.... Read More about Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes.

Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes (2011)
Journal Article
Cheng, F., Hope, C. N., Archibald, S. J., Bradley, J. S., Clark, S., Francesconi, M. G., Kelly, S. M., Young, N. A., & Lefebvre, F. (2011). Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes. International Journal of Applied Ceramic Technology, 8(2), 467-481. https://doi.org/10.1111/j.1744-7402.2009.02452.x

The preparation and molecular structures of two novel dimeric transition metal silylamide complexes {Li0.5Zr[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ -NSi(NMe2)3]}2 and {Li0.5Hf[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ-NSi(NMe2)3]}2 with a tetrahedral coordination e... Read More about Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes.

Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives (2010)
Journal Article
Jha, S., Silversides, J. D., Boyle, R. W., & Archibald, S. J. (2010). Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives. CrystEngComm RSC, 12(6), 1730-1739. https://doi.org/10.1039/b924683e

Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation... Read More about Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives.

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More about MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand (2009)
Journal Article
Mewis, R. E., Savoie, H., Archibald, S. J., & Boyle, R. W. (2009). Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand. Photodiagnosis and Photodynamic Therapy, 6(3-4), 200-206. https://doi.org/10.1016/j.pdpdt.2009.08.002

Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base... Read More about Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand.

CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Greenman, J., Pannecouque, C., Daelemans, D., Schols, D., De CLercq, E., Hubin, T. J., & Archibald, S. J. (2009). CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds. Antiviral research, 82(2), A59-A60. https://doi.org/10.1016/j.antiviral.2009.02.141

AMD3100 is a bis-azamacrocyclic compound that has been demonstrated to be a highly effective antagonist of the CXCR4 chemokine receptor. The two azamacrocyclic rings have been shown to interact with aspartate residues on the receptor via hydrogen bon... Read More about CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds.