All Outputs (76)

Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy (2016)
Journal Article
Elie, L., Elie, M., Cave, G., Vetter, M., Croxton, R., & Baron, M. (2016). Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy. Journal of Raman Spectroscopy, 47(11), 1343-1350. https://doi.org/10.1002/jrs.4957

Two new psychoactive substances, namely 4-methylmethcathinone (mephedrone) and 5,6-methylenedioxy-2-aminoindane (MDAI) were analysed with a novel combination of microcrystalline tests followed by Raman micro-spectroscopy to facilitate their absolute... Read More about Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy.

Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion (2016)
Journal Article
Mankouri, J., Walter, C., Stewart, H., Bentham, M., Park, W. S., Heo, W. D., …Harris, M. (2016). Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion. Journal of virology, 90(16), 7159-7170. https://doi.org/10.1128/jvi.00826-16

© 2016 Mankouri et al. The release of infectious hepatitis C virus (HCV) particles from infected cells remains poorly characterized. We previously demonstrated that virus release is dependent on the endosomal sorting complex required for transport (E... Read More about Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion.

Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium (2016)
Journal Article
Archer, L. K., Frame, F. M., & Maitland, N. J. (2017). Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium. Journal of Steroid Biochemistry and Molecular Biology, 166, 68-83. https://doi.org/10.1016/j.jsbmb.2016.05.006

Prostate cancer is the most common cancer of men in the UK and accounts for a quarter of all new cases. Although treatment of localised cancer can be successful, there is no cure for patients presenting with invasive prostate cancer and there are les... Read More about Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium.

Skin Microbiology☆ (2016)
Book
McBain, A., O’Neill, C., & Oates, A. (2016). Skin Microbiology☆. Elsevier. https://doi.org/10.1016/b978-0-12-801238-3.99217-1

In recent years the application of high throughput DNA sequencing for analyzing the composition of the skin microbiota has identified a highly diverse group of microorganisms. Although the factors determining the composition of the skin microbiota ar... Read More about Skin Microbiology☆.

Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines (2016)
Journal Article
Aydar, E., Stratton, D., Fraser, S. P., Djamgoz, M. B., & Palmer, C. (2016). Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines. European Biophysics Journal, 45(7), 671-683. https://doi.org/10.1007/s00249-016-1135-0

The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properti... Read More about Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.

RHOBTB3 (Rho-related BTB domain containing 3) (2016)
Journal Article
Cai, S., & Rivero, F. (2016). RHOBTB3 (Rho-related BTB domain containing 3). Atlas of genetics and cytogenetics in oncology and haematology, 20(12), https://doi.org/10.4267/2042/66947

RHOBTB3 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. In RHOBTB3 the GTPase doma... Read More about RHOBTB3 (Rho-related BTB domain containing 3).

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., …Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.

Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model (2016)
Journal Article
Wilkinson, H. N., McBain, A. J., Stephenson, C., & Hardman, M. J. (2016). Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model. Advances in wound care, 5(11), 475-485. https://doi.org/10.1089/wound.2015.0683

Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, thei... Read More about Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders (2016)
Journal Article
Simeoni, I., Stephens, J. C., Hu, F., Deevi, S. V. V., Megy, K., Bariana, T. K., …Turro, E. (2016). A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood, 127(23), 2791-2803. https://doi.org/10.1182/blood-2015-12-688267

Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often un... Read More about A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals (2016)
Journal Article
Taggart, M. P., Tarn, M. D., Esfahani, M. M. N., Schofield, D. M., Brown, N. J., Archibald, S. J., …Thompson, L. F. (2016). Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals. Lab on a chip, 16(9), 1605-1616. https://doi.org/10.1039/c6lc00099a

The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insuf... Read More about Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals.

Duramycin-induced calcium release in cancer cells (2016)
Journal Article
Broughton, L. J., Crow, C., Madden, L. A., & Maraveyas, A. (2016). Duramycin-induced calcium release in cancer cells. Anti-cancer drugs, 27(3), 173-182. https://doi.org/10.1097/cad.0000000000000313

Introduction: Duramycin through binding with phosphatidylethanolamine (PE) has shown potential to be an effective anti-tumour agent. However its mode of action in relation to tumour cells is not fully understood. Methods: PE expression on the surface... Read More about Duramycin-induced calcium release in cancer cells.

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 (2016)
Journal Article
Watson, C. N., Cox, D., Watson, S. P., Arman, M., Henderson, I. R., & Kerrigan, S. W. (2016). Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets, 27(6), 535-540. https://doi.org/10.3109/09537104.2016.1148129

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human p... Read More about Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

Signaling by PTK6 (2016)
Journal Article
Orlic-Milacic, M., & Pires, I. (2016). Signaling by PTK6. Reactome a knowledgebase of biological processes, 56, https://doi.org/10.3180/r-hsa-8848021.1

Multiplex sorting of foodborne pathogens by on-chip free-flow magnetophoresis (2016)
Journal Article
Ngamsom, B., Esfahani, M. M., Phurimsak, C., Lopez-Martinez, M. J., Raymond, J., Broyer, P., …Pamme, N. (2016). Multiplex sorting of foodborne pathogens by on-chip free-flow magnetophoresis. Analytica Chimica Acta, 918, 69-76. https://doi.org/10.1016/j.aca.2016.03.014

This study reports multiplex sorting of Salmonella typhimurium and Escherichia coli 0157, from broth cultures and from pathogen-spiked skinned chicken breast enrichment broths by employing microfluidic free-flow magnetophoresis. Magnetic beads of dif... Read More about Multiplex sorting of foodborne pathogens by on-chip free-flow magnetophoresis.

Microfluidics : the fur-free way towards personalised medicine in cancer therapy (2016)
Journal Article
Dawson, A., Greenman, J., Bower, R., & Green, V. (in press). Microfluidics : the fur-free way towards personalised medicine in cancer therapy. Drug target review, 3(1), 12-17

Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients. The maintenance of tissue in an in viv... Read More about Microfluidics : the fur-free way towards personalised medicine in cancer therapy.

An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells (2016)
Journal Article
Peitzsch, C., Cojoc, M., Hein, L., Kurth, I., Mäbert, K., Trautmann, F., …Dubrovska, A. (2016). An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells. Cancer Research, 76(9), 2637-2651. https://doi.org/10.1158/0008-5472.can-15-2116

Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to a population of cancer stem cells (CSC) that survi... Read More about An epigenetic reprogramming strategy to resensitize radioresistant prostate cancer cells.

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes (2016)
Journal Article
Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), 4977-4987. https://doi.org/10.1039/c6ce00209a

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure d... Read More about Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes.

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers (2016)
Journal Article
Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O’Shea, V., Pimlott, S. L., …Archibald, S. J. (2016). Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(45), 7221-7224. https://doi.org/10.1039/c6cc00660d

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-no... Read More about Positron detection in silica monoliths for miniaturised quality control of PET radiotracers.

RHOBTB2 (Rho-related BTB domain containing 2) (2016)
Journal Article
Cai, S., Rivero-Crespo, F., & Schenková, K. (2016). RHOBTB2 (Rho-related BTB domain containing 2). Atlas of genetics and cytogenetics in oncology and haematology,

RhoBTB2 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB2 is a putative tumo... Read More about RHOBTB2 (Rho-related BTB domain containing 2).

RHOBTB1 (Rho-related BTB domain containing 1) (2016)
Journal Article
Cai, S., Rivero-Crespo, F., & Schenková, K. (2016). RHOBTB1 (Rho-related BTB domain containing 1). Atlas of genetics and cytogenetics in oncology and haematology, 20(10), 512-515. https://doi.org/10.4267/2042/66084

RhoBTB1 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB1 is a putative tumo... Read More about RHOBTB1 (Rho-related BTB domain containing 1).