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Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging (2015)
Journal Article
Clemente, G. S., Burke, B. P., Nigam, S., Cawthorne, C., & Archibald, S. J. (2015). Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging. European journal of nuclear medicine and molecular imaging, 42(S1), S42. https://doi.org/10.1007/s00259-015-3198-z

Conference abstract

Pancreatic β-cell imaging in humans: Fiction or option? (2015)
Journal Article
Laurent, D., Vinet, L., Lamprianou, S., Daval, M., Filhoulaud, G., Ktorza, A., Wang, H., Sewing, S., Juretschke, H.-P., Glombik, H., Meda, P., Boisgard, R., Nguyen, D. L., Stasiuk, G. J., Long, N. J., Montet, X., Hecht, P., Kramer, W., Rutter, G. A., & Hecksher-Sørensen, J. (2016). Pancreatic β-cell imaging in humans: Fiction or option?. Diabetes, Obesity and Metabolism, 18(1), 6-15. https://doi.org/10.1111/dom.12544

Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12 adults. Treatment of disease complications typically consumes ∼10% of healthcare budgets in developed societies. Whilst immune‐mediated destruction of insulin‐secr... Read More about Pancreatic β-cell imaging in humans: Fiction or option?.

Analogue peptides for the immunotherapy of human acute myeloid leukemia (2015)
Journal Article
Hofmann, S., Mead, A., Malinovskis, A., Hardwick, N. R., & Guinn, B. A. (2015). Analogue peptides for the immunotherapy of human acute myeloid leukemia. Cancer Immunology, Immunotherapy, 64(11), 1357-1367. https://doi.org/10.1007/s00262-015-1762-9

The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the i... Read More about Analogue peptides for the immunotherapy of human acute myeloid leukemia.

Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise (2015)
Journal Article
Peart, D. J., Kirk, R. J., Madden, L. A., & Vince, R. V. (2016). Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise. Amino acids, 48(2), 499-504. https://doi.org/10.1007/s00726-015-2103-1

The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm,... Read More about Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise.

Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue (2015)
Journal Article
Cooper, N. H., Balachandra, J. P., & Hardman, M. J. (2015). Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue. Journal of Investigative Dermatology, 135(12), 3173-3182. https://doi.org/10.1038/jid.2015.338

The skin's mechanical integrity is maintained by an organized and robust dermal extracellular matrix (ECM). Resistance to mechanical disruption hinges primarily on homeostasis of the dermal collagen fibril architecture, which is regulated, at least i... Read More about Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue.

Regulation of adenosine receptor desensitisation and function (2015)
Book Chapter
Rutherford, C., & Palmer, T. M. (2015). Regulation of adenosine receptor desensitisation and function. In V. Ramkumar, & R. Paes de Carvalho (Eds.), Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects (35-53). Nova Science Publishers

© 2015 by Nova Science Publishers, Inc. All rights reserved. The ability of cells to respond to changes in extracellular concentrations of the nucleoside adenosine is determined by their complement of cell surface adenosine receptors. Four receptor s... Read More about Regulation of adenosine receptor desensitisation and function.

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable' (2015)
Journal Article
Morgan, K., Sadofsky, L. R., & Morice, A. H. (2015). Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Bioscience Reports, 35(5), Article e00255. https://doi.org/10.1042/BSR20150108

© 2015 Authors. Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signallin... Read More about Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate (2015)
Journal Article
Funwie, N. L., Cain, A. N., Fanning, B. Z., Hageman, S. A., Mullens, M., Roberts, T. K., Turner, D. J., Valdez, C. N., Vaughan, R. W., Ermias, H. G., Silversides, J. D., Archibald, S. J., Hubin, T. J., & Prior, T. J. (2015). Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate. Acta Crystallographica Section E: Crystallographic Communications, 71(9), 1073-1076. https://doi.org/10.1107/S2056989015015340

The title compound, [FeCl₂(C₁₄H₃₀N₄)]PF₆, contains Fe³⁺ coordinated by the four nitro­gen atoms of an ethyl­ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa­hedral environment. In contrast to other similar compound... Read More about Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate.

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo (2015)
Journal Article
Jorfi, S., Ansa-Addo, E. A., Kholia, S., Stratton, D., Valley, S., Lange, S., & Inal, J. (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific reports, 5(1), Article 13006. https://doi.org/10.1038/srep13006

Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could be used at lower concentrat... Read More about Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo.

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy (2015)
Journal Article
Pennock, R., Bray, E., Pryor, P., James, S., McKeegan, P., Sturmey, R., & Genever, P. (2015). Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Scientific reports, 5(1), Article ARTN 13113. https://doi.org/10.1038/srep13113

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacem... Read More about Human cell dedifferentiation in mesenchymal condensates through controlled autophagy.

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer (2015)
Journal Article
Jones, D., Wade, M., Nakjang, S., Chaytor, L., Grey, J., Robson, C. N., & Gaughan, L. (2015). FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer. Oncotarget, 6(30), 29782-29794. https://doi.org/10.18632/oncotarget.4927

Retention of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the requirement for the development of more effective AR targeting therapies. A key mechanism of resistance to anti-androgens is through expression... Read More about FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions (2015)
Journal Article
Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., Domarkas, J., Lorch, M., Pickles, M., Gibbs, P., Cawthorne, C., & Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describ... Read More about Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions.

Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway (2015)
Journal Article
Raslan, Z., Magwenzi, S., Aburima, A., Taskén, K., & Naseem, K. M. (2015). Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway. Journal of thrombosis and haemostasis : JTH, 13(9), 1721-1734. https://doi.org/10.1111/jth.13042

Background Platelet adhesion to von Willebrand factor (VWF) is modulated by 3′,5′-cyclic adenosine monophosphate (cAMP) signaling through protein kinase A (PKA)-mediated phosphorylation of glycoprotein (GP)Ibβ. A-kinase anchoring proteins (AKAPs) are... Read More about Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway.

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart (2015)
Journal Article
Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013. https://doi.org/10.1093/gerona/glv093

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies sugg... Read More about Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart.

Embryo metabolism : what does it really mean? (2015)
Journal Article
Sturmey, R., & Lewis, N. (2015). Embryo metabolism : what does it really mean?. Animal reproduction / Colegio Brasileiro de Reproducao Animal, 12(3), 521-528

The study of early embryo metabolism has fascinated researchers in the field for nearly a century. Herein, we give a brief account of the general features of embryo metabolism and some consideration of the research performed to reach such conclusions... Read More about Embryo metabolism : what does it really mean?.

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy (2015)
Journal Article
O’Neill, D., Jones, D., Wade, M., Grey, J., Nakjang, S., Guo, W., Cork, D., Davies, B. R., Wedge, S. R., Robson, C. N., & Gaughan, L. (2015). Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy. Oncotarget, 6(28), 26029-26040. https://doi.org/10.18632/oncotarget.4347

The persistence of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the unmet clinical need for the development of more effective AR targeting therapies. A key mechanism of therapy-resistance is by selection o... Read More about Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy.

The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management (2015)
Journal Article
Ladwiniec, A., & Hoye, A. (2015). The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management. International journal of cardiology, 198, 159-166. https://doi.org/10.1016/j.ijcard.2015.06.174

Physiological lesion assessment in the form of Fractional Flow Reserve (FFR) is now well established for the purpose of guiding multi-vessel revascularization. Chronic total coronary occlusions are frequently associated with multi-vessel disease and... Read More about The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management.

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands (2015)
Journal Article
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L., Herr, A. B., Pollitt, A. Y., O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E., & Watson, S. P. (2015). Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468(3), 459-473. https://doi.org/10.1042/BJ20150192

Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognized ligands, including diesel exhaust particles (DEP), small peptides [4N1-1, Champs (computed helical anti-membrane proteins),... Read More about Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9 (2015)
Journal Article
Stratton, D., Moore, C., Antwi-Baffour, S., Lange, S., & Inal, J. (2015). Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and biophysical research communications, 460(3), 589-595. https://doi.org/10.1016/j.bbrc.2015.03.074

© 2015 Elsevier Inc. All rights reserved. We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism... Read More about Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9.