The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study
(2019)
Journal Article
Smith, J. A., McGarvey, L., Morice, A. H., Birring, S. S., Wedzicha, J. A., Notari, M., …Jarreta, D. (2019). The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study. American Journal of Respiratory and Critical Care Medicine, 200(5), 642-645. https://doi.org/10.1164/rccm.201901-0048LE
All Outputs (71)
Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis (2019)
Journal Article
Lee, S. E., Lee, J., Kim, H. J., Lee, B., Cho, S., Price, D., …Song, W. (2019). Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis. Allergy Asthma and Immunology Research, 11(6), 856-870. https://doi.org/10.4168/aair.2019.11.6.856Purpose: Inhaled corticosteroids (ICSs) are often considered an empirical therapy in the management of patients with cough. However, ICS responsiveness is difficult to interpret in daily clinical practice, as the improvements may include placebo effe... Read More about Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis.
The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.
Therapeutic effects of Crocin in autoimmune diseases: A review (2019)
Journal Article
Korani, S., Korani, M., Sathyapalan, T., & Sahebkar, A. (2019). Therapeutic effects of Crocin in autoimmune diseases: A review. BioFactors, 45(6), 835-843. https://doi.org/10.1002/biof.1557The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple... Read More about Therapeutic effects of Crocin in autoimmune diseases: A review.
ATP cough challenge (2019)
Journal Article
Morice, A. (2019). ATP cough challenge. Pulmonary Pharmacology and Therapeutics, 58, Article 101835. https://doi.org/10.1016/j.pupt.2019.101835
A review of the pharmacological and therapeutic effects of auraptene (2019)
Journal Article
Bibak, B., Shakeri, F., Barreto, G. E., Keshavarzi, Z., Sathyapalan, T., & Sahebkar, A. (2019). A review of the pharmacological and therapeutic effects of auraptene. BioFactors, 45(6), 867-879. https://doi.org/10.1002/biof.1550There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the th... Read More about A review of the pharmacological and therapeutic effects of auraptene.
Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life Sciences, 234, Article 116776. https://doi.org/10.1016/j.lfs.2019.116776Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptid... Read More about Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity.
Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom (2019)
Journal Article
Drage, D. S., Heffernan, A. L., Cunningham, T. K., Aylward, L. L., Mueller, J. F., Sathyapalan, T., & Atkin, S. L. (2019). Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom. Environmental Research, 177, Article 108631. https://doi.org/10.1016/j.envres.2019.108631We investigated the serum concentrations of two brominated flame retardants (BFRs) – polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD) –in 59 women aged between 23 and 42 from the United Kingdom. We also collected demographic... Read More about Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom.
High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death (2019)
Journal Article
Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., Kazmi, S., …Cleland, J. G. (2020). High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death. Cardiovascular research, 116(1), 91-100. https://doi.org/10.1093/cvr/cvz198Aims: Plasma concentrations of high-sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP,... Read More about High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death.
The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study (2019)
Journal Article
Morice, A. H., Kitt, M. M., Ford, A. P., Tershakovec, A. M., Wu, W. C., Brindle, K., …Wright, C. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study. European respiratory journal, 54(1), Article 1900439. https://doi.org/10.1183/13993003.00439-2019We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge. In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant... Read More about The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study.
Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity (2019)
Journal Article
Featherby, S., Madkhali, Y., Maraveyas, A., & Ettelaie, C. (2019). Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity. Thrombosis and haemostasis, 119(9), 1419-1432. https://doi.org/10.1055/s-0039-1692682The activation of protease-activated receptor (PAR)-2 by factor Xa (fXa) promotes the release of tissue factor-positive microvesicles (TF + MV), and contributes to proliferation in cancer cells. This study examined the ability of direct oral anticoag... Read More about Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity.
Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct (2019)
Journal Article
Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., …Price, D. (2019). Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct. Health Technology Assessment, 23(37), 1-145. https://doi.org/10.3310/hta23370Background: Despite widespread use of therapies such as inhaled corticosteroids (ICSs), people with chronic obstructive pulmonary disease (COPD) continue to suffer, have reduced life expectancy and utilise considerable NHS resources. Laboratory inves... Read More about Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct.
Is weight loss harmful for skeletal health in obese older adults? (2019)
Journal Article
Papageorgiou, M., Kerschan-Schindl, K., Sathyapalan, T., & Pietschmann, P. (2020). Is weight loss harmful for skeletal health in obese older adults?. Gerontology, 66(1), 2-14. https://doi.org/10.1159/000500779Purpose of Review: In view of the existing uncertainty about the implications of intentional weight loss in older obese adults, the present review (a) summarizes the available evidence from epidemiological and interventional studies concerning the ef... Read More about Is weight loss harmful for skeletal health in obese older adults?.
A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication (2019)
Journal Article
Pymer, S., Palmer, J., Harwood, A. E., Ingle, L., Smith, G. E., & Chetter, I. C. (2019). A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication. Journal of vascular surgery, https://doi.org/10.1016/j.jvs.2019.03.050Background Intermittent claudication (IC) is the most common symptom of peripheral arterial disease, which significantly affects walking ability, functional capacity and quality of life. Supervised exercise programs (SEP) are recommended as first-lin... Read More about A systematic review of high-intensity interval training as an exercise intervention for intermittent claudication.
The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., …Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.
Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited (2019)
Journal Article
Keshavarzi, Z., Shakeri, F., Barreto, G. E., Bibak, B., Sathyapalan, T., & Sahebkar, A. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. BioFactors, 45(4), 517-535. https://doi.org/10.1002/biof.1516Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI... Read More about Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited.
Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial (2019)
Journal Article
Mosenzon, O., Blicher, T. M., Rosenlund, S., Eriksson, J., Heller, S., Hels, O. H., …Zhdanova, E. (2019). Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes and Endocrinology, 7(7), 515-527. https://doi.org/10.1016/S2213-8587%2819%2930192-5Background: Oral semaglutide is the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for glycaemic control in patients with type 2 diabetes. Type 2 diabetes is commonly associated with renal impairment, restricting treatment options. We ai... Read More about Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial.
Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage (2019)
Journal Article
Sathyapalan, T., Yaribeygi, H., Sahebkar, A., & Lhaf, F. (2019). Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage. Life Sciences, 231, Article 116538. https://doi.org/10.1016/j.lfs.2019.06.013Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular me... Read More about Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage.
Curcumin: a modulator of inflammatory signaling pathways in the immune system (2019)
Journal Article
Kahkhaie, K. R., Mirhosseini, A., Aliabadi, A., Mohammadi, A., Mousavi, M. J., Haftcheshmeh, S. M., …Sahebkar, A. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 27(5), 885-900. https://doi.org/10.1007/s10787-019-00607-3Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflamma... Read More about Curcumin: a modulator of inflammatory signaling pathways in the immune system.
Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes (2019)
Journal Article
Yaribeygi, H., Yaribeygi, A., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(3), 2214-2218. https://doi.org/10.1016/j.dsx.2019.05.023Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addi... Read More about Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes.