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Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy (2020)
Journal Article
Saleem, A., Helo, Y., Win, Z., Dale, R., Cook, J., Searle, G. E., & Wells, P. (2020). Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy. International journal of radiation oncology, biology, physics, 107(2), 370-376. https://doi.org/10.1016/j.ijrobp.2020.02.014

© 2020 Elsevier Inc. Purpose: Post radiation therapy (RT) lung fibrosis is a major barrier to improved cure rate in lung cancer. Integrin αvβ6 plays a key role in fibrogenesis by activating transforming growth factor-β. Positron emission tomography (... Read More about Integrin αvβ6 Positron Emission Tomography Imaging in Lung Cancer Patients Treated With Pulmonary Radiation Therapy.

A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome (2020)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2020). A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, 11, https://doi.org/10.1177/2042018820938305

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Metabolic sequelae associated with PCOS range from insulin resistance to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Insulin resistanc... Read More about A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome.

Incretins and microRNAs: Interactions and physiological relevance (2020)
Journal Article
Radbakhsh, S., Sathyapalan, T., Banach, M., & Sahebkar, A. (2020). Incretins and microRNAs: Interactions and physiological relevance. Pharmacological research : the official journal of the Italian Pharmacological Society, 153, Article 104662. https://doi.org/10.1016/j.phrs.2020.104662

MicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the... Read More about Incretins and microRNAs: Interactions and physiological relevance.

MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress (2020)
Journal Article
Ashrafizadeh, M., Ahmadi, Z., Samarghandian, S., Mohammadinejad, R., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2020). MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress. Life Sciences, 244, 117329. https://doi.org/10.1016/j.lfs.2020.117329

MicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable... Read More about MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress.

The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Iranpanah, H., Orafai, H. M., Jamialahmadi, T., & Sahebkar, A. (2020). The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sciences, 244, Article 117305. https://doi.org/10.1016/j.lfs.2020.117305

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially am... Read More about The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review.

Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility) (2020)
Journal Article
Higginson, I., Wilcock, A., Johnson, M. J., Bajwah, S., Lovell, N., Yi, D., Hart, S., Crosby, V., Poad, H., Currow, D., Best, E., & Brown, S. (2020). Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility). Thorax, 75(2), 176-179. https://doi.org/10.1136/thoraxjnl-2019-213879

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with... Read More about Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2020). Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes. Journal of Diabetes and its Complications, 34(4), Article 107518. https://doi.org/10.1016/j.jdiacomp.2019.107518

Aims: Investigate if abnormal glucose tolerance (AGT) affects post-myocardial infarction (MI) prognosis in patients with hospital-related hyperglycaemia (HRH) but without known diabetes mellitus (KDM). Methods: Post-MI survivors without KDM underwent... Read More about Newly diagnosed abnormal glucose tolerance determines post-MI prognosis in patients with hospital related hyperglycaemia but without known diabetes.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., Greetham, S., Doyle, B., Hayes, N., Rigby, A., Atkin, S. L., Courts, F. L., & Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes. Life Sciences, 241, Article 117152. https://doi.org/10.1016/j.lfs.2019.117152

GLP-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) are two classes of antidiabetic agents used in the management of diabetes based on incretin hormones. There is emerging evidence that they have anti-inflammatory effects... Read More about Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes.

Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study) (2019)
Journal Article
Lukey, P. T., Coello, C., Gunn, R., Parker, C., Wilson, F. J., Saleem, A., Garman, N., Costa, M., Kendrick, S., Onega, M., Kang’ombe, A. R., Listanco, A., Davies, J., Ramada-Magalhaes, J., Moz, S., Fahy, W. A., Maher, T. M., Jenkins, G., Passchier, J., & Marshall, R. P. (2020). Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study). European journal of nuclear medicine and molecular imaging, 47(4), 967-979. https://doi.org/10.1007/s00259-019-04586-z

© 2019, The Author(s). Purpose: The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy huma... Read More about Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study).

Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., Maleki, M., Jamialahmadi, T., & Sahebkar, A. (2020). Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review. Life Sciences, 240, Article 117090. https://doi.org/10.1016/j.lfs.2019.117090

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are a relatively newer class of anti-hyperglycemic medications that reduce blood glucose by inhibition of renal glucose re-uptake, thereby increasing urinary glucose excretion. Although glycosuria i... Read More about Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review.

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., Williamson, J. D., Hart, S. P., & Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis (2019)
Journal Article
Sin, D. D., O'Connor, G. T., Newell Jr., J. D., Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S. F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., …Wain, L. V. (2020). Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 201(5), 564-574. https://doi.org/10.1164/rccm.201905-1017OC

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of... Read More about Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis.

Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet (2019)
Journal Article
Ganie, M. A., Sahar, T., Rashid, A., Wani, I. A., Nisar, S., Sathyapalan, T., Vishnubhatla, S., Ramakrishnan, L., Parvez, T., & Geer, I. (2019). Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet. Frontiers in endocrinology, 10, Article 699. https://doi.org/10.3389/fendo.2019.00699

Background: Sub-inflammation and insulin resistance characterize women with PCOS. Data on dietary modulation of inflammation among PCOS women is scant, particularly from Indian subcontinent. The present study aimed to assess the effect of plant based... Read More about Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet.

Expression of microRNA in follicular fluid in women with and without PCOS (2019)
Journal Article
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., Sathyapalan, T., Najafi-Shoushtari, S. H., & Atkin, S. L. (2019). Expression of microRNA in follicular fluid in women with and without PCOS. Scientific reports, 9(1), Article 16306. https://doi.org/10.1038/s41598-019-52856-5

© 2019, The Author(s). Several studies have shown the expression of small non-coding microRNA (miRNA) changes in PCOS and their expression in follicular fluid has been described, though the number of studies remains small. In this prospective cohort... Read More about Expression of microRNA in follicular fluid in women with and without PCOS.

The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., & Sahebkar, A. (2019). The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sciences, 237, Article 116950. https://doi.org/10.1016/j.lfs.2019.116950

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstr... Read More about The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms.

Effects of curcumin on mitochondria in neurodegenerative diseases (2019)
Journal Article
Bagheri, H., Ghasemi, F., Barreto, G. E., Rafiee, R., Sathyapalan, T., & Sahebkar, A. (2020). Effects of curcumin on mitochondria in neurodegenerative diseases. BioFactors, 46(1), 5-20. https://doi.org/10.1002/biof.1566

Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., p... Read More about Effects of curcumin on mitochondria in neurodegenerative diseases.