All Outputs (29)

Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils (2009)
Journal Article
Vince, R. V., Chrismas, B., Midgley, A. W., McNaughton, L. R., & Madden, L. A. (2009). Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils. Oxidative Medicine and Cellular Longevity, 2(1), 2-6. https://doi.org/10.4161/oxim.2.1.7611

Microparticles are released from the endothelium under normal homeostatic conditions and have been shown elevated in disease states, most notably those characterised by endothelial dysfunction. The endothelium is sensitive to oxidative stress/status... Read More about Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils.

Coordination chemistry of macrocyclic ligands (2009)
Journal Article
Archibald, S. J. (2009). Coordination chemistry of macrocyclic ligands. Annual Reports Section A :Inorganic Chemistry, 105, 297 - 322. https://doi.org/10.1039/b818281g

This chapter reviews the literature published during 2008 on macrocyclic coordination chemistry. Porphyrin ligands and supramolecular chemistry are not covered in this review which primarily focuses on complexes formed with transition metals and lant... Read More about Coordination chemistry of macrocyclic ligands.

Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme (2009)
Journal Article
Ngamsom, B., Hickey, A. M., Greenway, G. M., Littlechild, J. A., Watts, P., & Wiles, C. (2010). Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme. Journal of Molecular Catalysis B: Enzymatic, 63(1-2), 81-86. https://doi.org/10.1016/j.molcatb.2009.12.013

Micro-reactors containing a monolith-immobilised thermophilic l-aminoacylase, from Thermococcus litoralis, have been developed for use in biotransformation reactions and a study has been carried out to investigate the stereospecificity and stability... Read More about Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme.

Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system (2009)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2010). Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system. Process Biochemistry, 45(4), 593-597. https://doi.org/10.1016/j.procbio.2009.12.008

This paper reports a simple method for producing macroporous silica-monoliths with controllable porosity that can be used for the immobilization of lipases to generate an active and stable micro-reactor for biocatalysis. A range of commercially avail... Read More about Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system.

Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection (2009)
Journal Article
He, P., Davies, J., Greenway, G., & Haswell, S. J. (2010). Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Analytica Chimica Acta, 659(1-2), 9-14. https://doi.org/10.1016/j.aca.2009.11.052

This paper reports a simple μ-FIA based method for the rapid evaluation of acetylcholinesterase inhibition based on bienzymes immobilized monolith micro-reactor, with integrated electrochemical detection. The monolith was prepared inside a micro-flui... Read More about Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection.

TRPA1 agonists evoke coughing in guinea pig and human volunteers (2009)
Journal Article
Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., …Morice, A. H. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180(11), 1042-1047. https://doi.org/10.1164/rccm.200905-0665OC

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is als... Read More about TRPA1 agonists evoke coughing in guinea pig and human volunteers.

Detection of nitric oxide in tissue samples by ESI-MS (2009)
Journal Article
Shen, Z., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., & Haswell, S. J. (2010). Detection of nitric oxide in tissue samples by ESI-MS. Analyst, 135(2), 302-305. https://doi.org/10.1039/b917643h

A novel method to determine nitric oxide (NO) in biological tissue samples with minimal interference from the cellular detritus is described. Methylpiperazinobenzenediamine, consisting of an o-phenylenediamine and a methyl piperazine group, was chose... Read More about Detection of nitric oxide in tissue samples by ESI-MS.

IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells (2009)
Journal Article
Caserta, S., Alessi, P., Basso, V., & Mondino, A. (2010). IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells. European journal of immunology, 40(2), 470-479. https://doi.org/10.1002/eji.200939801

It is well established that tumours hinder both natural and vaccine-induced tumourspecific CD4 + T-cell responses. Adoptive T-cell therapy has the potential to circumvent functional tolerance and enhance anti-tumour protective responses. While proto... Read More about IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells.

Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain (2009)
Journal Article
Roberts, W., Michno, A., Aburima, A., & Naseem, K. M. (2009). Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain. Journal of thrombosis and haemostasis : JTH, 7(12), 2106-2115. https://doi.org/10.1111/j.1538-7836.2009.03619.x

Background: von Willebrand factor (VWF)-mediated platelet adhesion and spreading at sites of vascular injury is a critical step in hemostasis. This process requires two individual receptors: glycoprotein Ib (GPIb)-V-IX and integrin αIIbβ3. However, l... Read More about Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain.

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More about MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand (2009)
Journal Article
Mewis, R. E., Savoie, H., Archibald, S. J., & Boyle, R. W. (2009). Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand. Photodiagnosis and Photodynamic Therapy, 6(3-4), 200-206. https://doi.org/10.1016/j.pdpdt.2009.08.002

Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base... Read More about Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand.

Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers (2009)
Journal Article
Croxton, R., Lee, J., Bleay, S., Sears, V., & Mehmet, S. (2009). Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers. Journal of Forensic Identification, 59(5), 545-568

The use of dimethylaminocinnemaldehyde (DMAC) as a fingerprint development reagent was first proposed in the 1970s as a solution-dipping technique to target the urea constituent of fingerprints. However, in operational trials, the quality of develope... Read More about Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers.

Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing (2009)
Journal Article
Dou, Y., Haswell, S., Greenman, J., & Wadhawan, J. (2009). Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing. Electrochemistry communications, 11(10), 1976-1981. https://doi.org/10.1016/j.elecom.2009.08.032

The detection of hydrogen peroxide is detailed using horseradish peroxidase and anthraquinone. Both species are immobilized on a glassy carbon electrode substrate. This dual immobilization gives rise to lower detection limits compared with the situat... Read More about Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing.

Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser (2009)
Journal Article
Oakley, J. A., Robinson, S., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Analytica Chimica Acta, 652(1-2), 239-244. https://doi.org/10.1016/j.aca.2009.07.063

An integrated gel supported micro-fluidic system is reported, in which PCR products can be efficiently injected into a capillary electrophoresis device. The gel supported system is designed to provide greater stability to reagents during long periods... Read More about Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser.

Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics (2009)
Journal Article
Greenway, G., Haswell, S. J., & He, P. (2010). Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics. Microfluidics and Nanofluidics, 8(5), 565-573. https://doi.org/10.1007/s10404-009-0476-8

This paper describes a simple and efficient method for producing an on-chip enzyme immobilized monolith micro-reactor that integrates a microfluidic electrochemical cell for rapid characterization of enzymatic kinetics. The monolith was generated usi... Read More about Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics.

Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions (2009)
Conference Proceeding
Sturge, J. (2009). Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions.

A major clinical complication in patients with advanced prostate cancer is metastasis to bone where osteoblastic and/or osteoclastic activity results in a highly destructive tissue remodelling process.Recent in vivo studies have identified important... Read More about Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions.

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation (2009)
Journal Article
Colasante, C., Peña Diaz, P., Clayton, C., & Voncken, F. (2009). Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation. Molecular and Biochemical Parasitology, 167(2), 104-117. https://doi.org/10.1016/j.molbiopara.2009.05.004

The mitochondrial carrier family (MCF) is a group of structurally conserved proteins that mediate the transport of a wide range of metabolic intermediates across the mitochondrial inner membrane. In this paper, an overview of the mitochondrial carrie... Read More about Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation.

COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines (2009)
Journal Article
O'Kane, S. L., Eagle, G. L., Greenman, J., Lind, M. J., & Cawkwell, L. (2010). COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. Lung Cancer, 67(2), 160-165. https://doi.org/10.1016/j.lungcan.2009.04.008

BACKGROUND Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average survival of 10 months from diagnosis. The choice of chemotherapy regimens for mesothelioma patients is l... Read More about COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines.

CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Greenman, J., Pannecouque, C., Daelemans, D., …Archibald, S. J. (2009). CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds. Antiviral research, 82(2), A59-A60. https://doi.org/10.1016/j.antiviral.2009.02.141

AMD3100 is a bis-azamacrocyclic compound that has been demonstrated to be a highly effective antagonist of the CXCR4 chemokine receptor. The two azamacrocyclic rings have been shown to interact with aspartate residues on the receptor via hydrogen bon... Read More about CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds.

Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity (2009)
Journal Article
Amthor, H., Otto, A., Vulin, A., Rochat, A., Dumonceaux, J., Garcia, L., …Partridge, T. (2009). Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity. Proceedings of the National Academy of Sciences of the United States of America, 106(18), 7479-7484. https://doi.org/10.1073/pnas.0811129106

Myostatin, a member of the TGF-β family, has been identified as a powerful inhibitor of muscle growth. Absence or blockade of myostatin induces massive skeletal muscle hypertrophy that is widely attributed to proliferation of the population of muscle... Read More about Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity.