Projects (482)

Development and application of a multi-scale computational model of sarcoidosis to predict therapeutic approaches for non-self-resolving disease Jun 30, 2017 - Aug 31, 2020
An in silico computational model of sarcoidosis

RDSI: A randomised controlled trial to determine the clinical and cost effectiveness of a self-management intervention for the respiratory distress symptom cluster (breathlessness-cough-fatigue) in lung cancer Jan 1, 2017 - May 31, 2019

A Double-blind, Randomized, Parallel-group, Placebo-controlled Study of MLE4901 for the Treatment of Polycystic Ovary Syndrome (PCOS) Jan 11, 2017 - Jan 10, 2018

Galactic-HF: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction Apr 1, 2017 - Jul 31, 2021
Acronym is derived from : Global approach to lowering adverse cardiac outcomes through improving contractility in heart failure.
A phase III randomised placebo controlled clinical trial sponsored by Amgen Inc of omecamtiv mercabil, a study drug whic... Read More about Galactic-HF: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction.

MICA: The role of arginase in chronic delayed wound healing Aug 1, 2016 - Oct 17, 2017

Does glycated hemoglobin variability in type 2 diabetes differ depending on the diabetes treatment used in the Qatari population: implication on diabetes complication risk Aug 1, 2016 - Jul 31, 2020
The purpose of this research is to better understand diabetes control and diabetes complications. It has been shown that fluctuation (changes) in long-term diabetes control may be related to the development of diabetes complications. In order to unde... Read More about Does glycated hemoglobin variability in type 2 diabetes differ depending on the diabetes treatment used in the Qatari population: implication on diabetes complication risk.

Evaluation of the SMASH programme Apr 1, 2017 - Jul 31, 2021
The aim of the proposal is to evaluate the effectiveness of the SMASH programme from the period September 2014 to February 2017 in terms of improved outcomes for children / young people, their families and schools. We will collate and summarise exist... Read More about Evaluation of the SMASH programme.

FRAIL-HEART: Assessment of Frailty in Elderly People with Ischemic Heart Disease being considered for Revascularisation: An Observational study Apr 1, 2017 - Mar 31, 2020
To summarise the study, we will recruit patients aged 80 years or more who attend the cardiology and cardio-thoracic departments of Castle Hill Hospital, Hull and who have been given a diagnosis of coronary artery disease. The patients will be identi... Read More about FRAIL-HEART: Assessment of Frailty in Elderly People with Ischemic Heart Disease being considered for Revascularisation: An Observational study.

REDUCE: REviewing long term anti-Depressant Use by Careful monitoring in Everyday practice programme Oct 1, 2016 - Jun 30, 2023
There is considerable concern about increasing antidepressant use in England, as in other countries. Prescriptions have increased year on year since the early 1990s, and GPs in England are giving out more than 50 million prescriptions every year, to... Read More about REDUCE: REviewing long term anti-Depressant Use by Careful monitoring in Everyday practice programme.

Translational Research in the Molecular Imaging Research Centre Aug 1, 2016 - Jul 31, 2018

Addictions: In Words and Pictures May 1, 2017 - Oct 31, 2018
People recovering from addictions will work with a lens based artist and a psychologist to illustrate their life stories in words and pictures. The process will have an impact upon participants directly, and produce a record to influence public perce... Read More about Addictions: In Words and Pictures.

Bringing breathlessness into view May 1, 2017 - Aug 31, 2017
People living with breathlessness find their experience hard to describe, so hide it from others. This workshop brings together local people with breathlessness and a Hull-based artist to create the ideas for a public photographic exhibition showing... Read More about Bringing breathlessness into view.

The Hidden Art of the Lullaby Apr 1, 2017 - Oct 31, 2018
Using simple, neglected or hidden lullabies sourced in Hull singing communities we will explore the journey of parents singing lullabies to their unborn/young baby, to promote parent-infant bonding and attachment, particularly during adversity e.g. p... Read More about The Hidden Art of the Lullaby.

Research Assistant: Baby Lifeline Evaluation Nov 1, 2017 - Oct 31, 2018
This is an evaluation of the impact of Baby lifeline training on neonatal and maternal outcomes.

BREATHE: Breathlessness RElief AT HomE Apr 1, 2019 - Oct 31, 2021
A feasibility study to address this RQ:
Does a paramedic-administered short non-pharmacological complex breathlessness intervention improve breathlessness and reduce conveyance to ED for people with breathlessness crisis compared with usual practice... Read More about BREATHE: Breathlessness RElief AT HomE.

The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro... Read More about The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture..

LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy Jun 1, 2018 - Feb 28, 2022
Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through... Read More about LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy.

C-Change: Delivering quality and cost-effective care across the range of complexity for those with advanced conditions in the last year of life Feb 27, 2017 - Sep 30, 2018

RESOLVE: Improving Health Status and Experience of Pain and other Symptoms for People with Advanced Cancer Jun 1, 2018 - Jan 28, 2024
In Yorkshire, over 14,000 people die from advanced cancer each year, a number expected to rise to 17,000 yearly by 2030. In the weeks or months before they die, people with advanced cancer often experience pain, breathlessness or fatigue-exhaustion,... Read More about RESOLVE: Improving Health Status and Experience of Pain and other Symptoms for People with Advanced Cancer.

VOLCANO-2: A double-blind, placebo controlled study of the efficacy and safety of three doses of Orvepitant in subjects with chronic refractory cough Aug 1, 2017 - Dec 31, 2019