Projects (482)

Knee Pain Method Validation Collaboration Jan 1, 2016 - Jul 31, 2017

Commander: A randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of Rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery diseas Oct 1, 2015 - May 31, 2018

Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature? Jul 1, 2015 - Jun 30, 2020
The study aims to demonstrate the indirect effect of Apixaban on suppressing the release of pro-inflammatory, pro-coagulant tissue factor-containing microvesicles, by inhibiting factor Xa and preventing the activation of PAR2. The study also demonstr... Read More about Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature?.

Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the... Read More about Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies.

Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017

A multi-centre, randomized, double-blind, placebo-controlled phase II study to assess the effect of Serelaxin versus placebo on high-sensitivity cardia troponin I (hs-cTnl) release in patients with chronic heart failure after exercise when used in additio Feb 18, 2016 - Feb 17, 2017
Numerous pathophysiological mechanisms are responsible for heart failure such as myocardial injury, oxidative stress, neuro-hormonal activation, inflammation, fibrosis and apoptosis. Besides B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT... Read More about A multi-centre, randomized, double-blind, placebo-controlled phase II study to assess the effect of Serelaxin versus placebo on high-sensitivity cardia troponin I (hs-cTnl) release in patients with chronic heart failure after exercise when used in additio.

CANAssess: Reducing inequalities in care for people with cancer and palliative care needs: a programme of work for cancer patients and caregivers in the community based in Yorkshire Sep 1, 2016 - Jan 30, 2019
People with cancer need good access to palliative care to relieve distressing symptoms, but some get better access than others. Developed in Australia, the Needs Assessment Tool - Progressive Disease Cancer (NAT:PD-C) is a tested, "everyday practice"... Read More about CANAssess: Reducing inequalities in care for people with cancer and palliative care needs: a programme of work for cancer patients and caregivers in the community based in Yorkshire.

Iron and Heart: A pilot trial of the effect of intravenous iron supplementation (Mononfer) in deficient but not anaemic patients with chronic kidney disease stages 3b or worse on functional status and cardiac structure and function Jun 1, 2015 - Sep 30, 2019
Clincal Trial

The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from... Read More about The Hull-Norwich Gut-Brian Study.

OSPREY: An Observational Study of the Phenotype and pRescribing in East Yorkshire and its relevance to the introduction of new prescribing guidelines for airways disease. Oct 1, 2016 - Dec 31, 2018

Development of Heavy Metal Free Quantum dot Lanthanide Conjugates for Sensing Aug 16, 2016 - Dec 31, 2018
The overall aim of this project to use innovative inorganic chemistry for the supramolecular self-assembly of novel heavy metal free nanocrystal (quantum dots) and lanthanide complexes to give multimodal contrast agents for molecular imaging. Key goa... Read More about Development of Heavy Metal Free Quantum dot Lanthanide Conjugates for Sensing.

Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public... Read More about Lab on a Chip NC3Rs Engagement Award.

Development and Validation of the Adolescent Sport Drug Inventory (ASDI) and Factors that Influence Attitudes among Adolescents Jan 1, 2014 - Sep 30, 2025
The primary aim of this project is to develop and then validate the Adolescent Sport Drug Inventory (ASDI) among adolescent athletes from different cultures (UK, US, Hong Kong, and Australia) and then use the ASDI to explore maturational, environment... Read More about Development and Validation of the Adolescent Sport Drug Inventory (ASDI) and Factors that Influence Attitudes among Adolescents.

CS-Y Studies: Understanding and reducing inequalities for people with cancer: A programme of work based in Yorkshire Aug 1, 2013 - Sep 30, 2017

Respond CRT-D Jan 10, 2013 - Feb 8, 2017

Orbit-4: A multi-centre, randomised, double-blind, placebo-controlled study to evaluate the safety and efficacy of Pulmaquin in the management of chronic lung infections with pseudomonas aeruginosa in subjects with non-cystic fibrosis bronchiectasis, including 28 Oct 31, 2014 - Jul 31, 2018

TUF: The Utility of FeNo in the differential diagnosis of chronic cough Nov 2, 2015 - Jun 1, 2018

Development Costs: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects Oct 5, 2015 - Oct 4, 2017

The Effectiveness of the Play Clean Group Based and the Mobile Applications (iPlayClean) Anti-Doping Education Programs for Adolescent Athletes and their Entourage: A Randomized Control Trial Nov 1, 2016 - Apr 30, 2026
This program of research will examine the effectiveness of the group based and website anti-doping education programs for high-level adolescent athletes and their entourage (i.e., coaches and parents). David Howman, the WADA director general, recentl... Read More about The Effectiveness of the Play Clean Group Based and the Mobile Applications (iPlayClean) Anti-Doping Education Programs for Adolescent Athletes and their Entourage: A Randomized Control Trial.

Advancing Care Coordination and Telehealth deployment at Scale - ACT@Scale Apr 1, 2016 - Mar 31, 2019