All Outputs (54)

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo (2015)
Journal Article
Jorfi, S., Ansa-Addo, E. A., Kholia, S., Stratton, D., Valley, S., Lange, S., & Inal, J. (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific reports, 5(1), Article 13006. https://doi.org/10.1038/srep13006

Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could be used at lower concentrat... Read More about Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo.

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy (2015)
Journal Article
Pennock, R., Bray, E., Pryor, P., James, S., McKeegan, P., Sturmey, R., & Genever, P. (2015). Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Scientific reports, 5(1), Article ARTN 13113. https://doi.org/10.1038/srep13113

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacem... Read More about Human cell dedifferentiation in mesenchymal condensates through controlled autophagy.

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer (2015)
Journal Article
Jones, D., Wade, M., Nakjang, S., Chaytor, L., Grey, J., Robson, C. N., & Gaughan, L. (2015). FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer. Oncotarget, 6(30), 29782-29794. https://doi.org/10.18632/oncotarget.4927

Retention of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the requirement for the development of more effective AR targeting therapies. A key mechanism of resistance to anti-androgens is through expression... Read More about FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions (2015)
Journal Article
Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., Domarkas, J., Lorch, M., Pickles, M., Gibbs, P., Cawthorne, C., & Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describ... Read More about Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions.

Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway (2015)
Journal Article
Raslan, Z., Magwenzi, S., Aburima, A., Taskén, K., & Naseem, K. M. (2015). Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway. Journal of thrombosis and haemostasis : JTH, 13(9), 1721-1734. https://doi.org/10.1111/jth.13042

Background Platelet adhesion to von Willebrand factor (VWF) is modulated by 3′,5′-cyclic adenosine monophosphate (cAMP) signaling through protein kinase A (PKA)-mediated phosphorylation of glycoprotein (GP)Ibβ. A-kinase anchoring proteins (AKAPs) are... Read More about Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway.

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart (2015)
Journal Article
Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013. https://doi.org/10.1093/gerona/glv093

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies sugg... Read More about Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart.

Embryo metabolism : what does it really mean? (2015)
Journal Article
Sturmey, R., & Lewis, N. (2015). Embryo metabolism : what does it really mean?. Animal reproduction / Colegio Brasileiro de Reproducao Animal, 12(3), 521-528

The study of early embryo metabolism has fascinated researchers in the field for nearly a century. Herein, we give a brief account of the general features of embryo metabolism and some consideration of the research performed to reach such conclusions... Read More about Embryo metabolism : what does it really mean?.

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy (2015)
Journal Article
O’Neill, D., Jones, D., Wade, M., Grey, J., Nakjang, S., Guo, W., Cork, D., Davies, B. R., Wedge, S. R., Robson, C. N., & Gaughan, L. (2015). Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy. Oncotarget, 6(28), 26029-26040. https://doi.org/10.18632/oncotarget.4347

The persistence of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the unmet clinical need for the development of more effective AR targeting therapies. A key mechanism of therapy-resistance is by selection o... Read More about Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy.

The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management (2015)
Journal Article
Ladwiniec, A., & Hoye, A. (2015). The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management. International journal of cardiology, 198, 159-166. https://doi.org/10.1016/j.ijcard.2015.06.174

Physiological lesion assessment in the form of Fractional Flow Reserve (FFR) is now well established for the purpose of guiding multi-vessel revascularization. Chronic total coronary occlusions are frequently associated with multi-vessel disease and... Read More about The haemodynamic effects of collateral donation to a chronic total occlusion : implications for patient management.

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands (2015)
Journal Article
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L., Herr, A. B., Pollitt, A. Y., O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E., & Watson, S. P. (2015). Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468(3), 459-473. https://doi.org/10.1042/BJ20150192

Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognized ligands, including diesel exhaust particles (DEP), small peptides [4N1-1, Champs (computed helical anti-membrane proteins),... Read More about Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9 (2015)
Journal Article
Stratton, D., Moore, C., Antwi-Baffour, S., Lange, S., & Inal, J. (2015). Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and biophysical research communications, 460(3), 589-595. https://doi.org/10.1016/j.bbrc.2015.03.074

© 2015 Elsevier Inc. All rights reserved. We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism... Read More about Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9.

Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation (2015)
Journal Article
ElKeeb, A. M., Collier, M. E. W., Maraveyas, A., & Ettelaie, C. (2015). Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis, 114(2), 364-378. https://doi.org/10.1160/th14-09-0795

We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial. In this study, TF-mediated mechanisms of induction of apoptosis were explored. Endothelial cells were transfected to express wild-type TF. Add... Read More about Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation.

Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis (2015)
Journal Article
Arman, M., & Krauel, K. (2015). Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis. Journal of thrombosis and haemostasis : JTH, 13(6), 893-908. https://doi.org/10.1111/jth.12905

© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasis and thrombosis, platelets are increasingly recognized as having immunologic functions. Supporting this, human platelets express FcγRIIA (CD32a), a l... Read More about Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis.

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells (2015)
Journal Article
Hirst, A. M., Simms, M. S., Mann, V. M., Maitland, N. J., O'Connell, D., & Frame, F. M. (2015). Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells. The British Journal of Cancer, 112(9), 1536-1545. https://doi.org/10.1038/bjc.2015.113

Background:
In recent years, the rapidly advancing field of low-temperature atmospheric pressure plasmas has shown considerable promise for future translational biomedical applications, including cancer therapy, through the generation of reactive ox... Read More about Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells.

The future of EPAC-targeted therapies: Agonism versus antagonism (2015)
Journal Article
Parnell, E., Palmer, T. M., & Yarwood, S. J. (2015). The future of EPAC-targeted therapies: Agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), 203-214. https://doi.org/10.1016/j.tips.2015.02.003

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes. Recent attention has turned to the specific regulation of EPAC... Read More about The future of EPAC-targeted therapies: Agonism versus antagonism.

αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia (2015)
Journal Article
Buitrago, L., Rendon, A., Liang, Y., Simeoni, I., Negri, A., ThromboGenomics Consortium, Filizola, M., Ouwehand, W. H., & Coller, B. S. (2015). αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia. Proceedings of the National Academy of Sciences of the United States of America, 112(15), E1898-E1907. https://doi.org/10.1073/pnas.1422238112

Next-generation sequencing is transforming our understanding of human genetic variation but assessing the functional impact of novel variants presents challenges. We analyzed missense variants in the integrin αIIbβ3 receptor subunit genes ITGA2B and... Read More about αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia.

Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)) (2015)
Journal Article
Pefani, D. E., Latusek, R., Pires, I., Grawenda, A. M., Yee, K. S., Hamilton, G., Van Der Weyden, L., Esashi, F., Hammond, E. M., & O'neill, E. (2015). Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)). Nature Cell Biology, 17(4), 531. https://doi.org/10.1038/ncb3152

Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation (2015)
Journal Article
Collins-Hooper, H., Sartori, R., Giallourou, N., Matsakas, A., Mitchell, R., Mararenkova, H., Flasskamp, H., Macharia, R., Ray, S., Swann, J. R., Sandri, M., & Patel, K. (2015). Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation. PLoS ONE, 10(3), e0120524. https://doi.org/10.1371/journal.pone.0120524

Animals are imbued with adaptive mechanisms spanning from the tissue/organ to the cellular scale which insure that processes of homeostasis are preserved in the landscape of size change. However we and others have postulated that the degree of adapta... Read More about Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation.

Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve (2015)
Journal Article
Ladwiniec, A., Cunnington, M. S., Rossington, J., Mather, A. N., Alahmar, A., Oliver, R. M., Nijjer, S. S., Davies, J. E., Thackray, S., Alamgir, F., & Hoye, A. (2015). Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve. Circulation. Cardiovascular interventions, 8(4), Article UNSP e002219. https://doi.org/10.1161/CIRCINTERVENTIONS.114.002219

Background— The presence of a concomitant chronic total coronary occlusion (CTO) and a large collateral contribution might alter the fractional flow reserve (FFR) of an interrogated vessel, rendering the FFR unreliable at predicting ischemia should t... Read More about Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve.

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia (2015)
Journal Article
Wangüemert, F., Bosch Calero, C., Pérez, C., Campuzano, O., Beltran-Alvarez, P., Scornik, F. S., Iglesias, A., Berne, P., Allegue, C., Ruiz Hernandez, P. M., Brugada, J., Pérez, G. J., & Brugada, R. (2015). Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia. Heart rhythm : the official journal of the Heart Rhythm Society, 12(7), 1636-1643. https://doi.org/10.1016/j.hrthm.2015.03.033

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth. Objectives... Read More about Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia.