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Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien) (2024)
Presentation / Conference Contribution
(2024, September). Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien). Presented at SimBio-M 2024, Online

This conference introduces new technologies, advances and tools in the various fields of Simulation in Biosciences and Multiphysics, notably in the areas of BioMechanics, BioMaterials, and BioMedicine.

While the conference concentrates mainly on t... Read More about Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien).

Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women (2023)
Journal Article
Dostan, A., Dobson, C. A., & Vanicek, N. (2023). Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women. PLoS ONE, 18(3), Article e0283333. https://doi.org/10.1371/journal.pone.0283333

Stair ascent is a biomechanically challenging task for older women. Bone health may affect gait stability during stair walking. This study investigated the gait biomechanics associated with stair ascent in a group of postmenopausal women in relation... Read More about Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women.

Microfluidic-based 3D bioprinting to fabricate blood vasculature (2023)
Presentation / Conference Contribution
Moetazedian, A., Cox, L., Grover, L., & Poologasundarampillai, G. (2022, June). Microfluidic-based 3D bioprinting to fabricate blood vasculature. Presented at UK Society for Biomaterials 22nd Annual Conference (UKSB 2022), University of Sheffield

Introduction:
The most substantial healthcare challenge facing the UK is the inevitable transition towards ageing population. Organ transplantation as the gold-standard treatment has saved many lives and millions of pounds for the NHS; however, ever... Read More about Microfluidic-based 3D bioprinting to fabricate blood vasculature.

The biomechanical role of the chondrocranium and the material properties of cartilage (2020)
Journal Article
Jones, M. E. H., Gröning, F., Aspden, R. M., Dutel, H., Sharp, A., Moazen, M., Fagan, M. J., & Evans, S. E. (2020). The biomechanical role of the chondrocranium and the material properties of cartilage. Vertebrate Zoology, 70(4), 699-715. https://doi.org/10.26049/VZ70-4-2020-10

The chondrocranium is the cartilage component of the vertebrate braincase. Among jawed vertebrates it varies greatly in structure, mineralisation, and in the extent to which it is replaced by bone during development. In mammals, birds, and some bony... Read More about The biomechanical role of the chondrocranium and the material properties of cartilage.

Viscoelastically active sutures – A stitch in time? (2020)
Journal Article
France, L. A., & Fancey, K. S. (2021). Viscoelastically active sutures – A stitch in time?. Materials Science and Engineering: C, 121, Article 111695. https://doi.org/10.1016/j.msec.2020.111695

We present results to show that a commercially available polypropylene suture filament (Ethicon Prolene), following annealing and tensile creep can, after creep load removal, release viscoelastically stored energy over a period of several weeks. Spec... Read More about Viscoelastically active sutures – A stitch in time?.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise (2020)
Journal Article
Al-Karadi, M. S., & Langley, P. (2020). Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise. Sensors, 20(14), 1-12. https://doi.org/10.3390/s20144029

The reporting of U wave abnormalities is clinically important, but the measurement of this small electrocardiographic (ECG) feature is extremely difficult, especially in challenging recording conditions, such as stress exercise, due to contaminating... Read More about Multi-beat averaging reveals u waves are ubiquitous and standing tall at elevated heart rates following exercise.

The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study (2020)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (in press). The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study. Computer methods in biomechanics and biomedical engineering, https://doi.org/10.1080/10255842.2020.1777546

Remodelling and adaptation of bone within the pelvis is believed to be influenced by the mechanical strains generated during locomotion. Variation in the cortical bone thickness observed in the prenatal ilium has been linked to the musculoskeletal lo... Read More about The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.

Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering (2019)
Journal Article
Mani, M. P., Jiang, H., Mani, M. P., & Jaganathan, S. K. (2019). Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering. International Journal of Nanomedicine, 14, 8149-8159. https://doi.org/10.2147/IJN.S214646

Introduction: Recently several new approaches were emerging in bone tissue engineering to develop a substitute for remodelling the damaged tissue. In order to resemble the native extracellular matrix (ECM) of the human tissue, the bone scaffolds must... Read More about Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering.

A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth (2019)
Journal Article
Pinheiro, M., Ma, X., Fagan, M. J., McIntyre, G. T., Lin, P., Sivamurthy, G., & Mossey, P. A. (2019). A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth. Journal of Biological Engineering, 13(1), https://doi.org/10.1186/s13036-019-0171-6

© 2019 The Author(s). Background: Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal planes and... Read More about A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth.

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., Herrel, A., Santin, M. D., Clément, G., & Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More about Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Characterizing and Modeling Bone Formation during Mouse Calvarial Development (2019)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), Article 048103. https://doi.org/10.1103/PhysRevLett.122.048103

© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as c... Read More about Characterizing and Modeling Bone Formation during Mouse Calvarial Development.

An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus) (2018)
Journal Article
Sellés de Lucas, V., Dutel, H., Evans, S. E., Gröning, F., Sharp, A. C., Watson, P. J., & Fagan, M. J. (2018). An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus). Interface, 15(147), Article 20180278. https://doi.org/10.1098/rsif.2018.0278

© 2018 The Author(s). The falx cerebri and the tentorium cerebelli are two projections of the dura mater in the cranial cavity which ossify to varying degrees in some mammalian species. The idea that the ossification of these structures may be necess... Read More about An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus).

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), Article 11946. https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More about Validation of an algorithm to reveal the U wave in atrial fibrillation.

Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density (2018)
Journal Article
Dostanpor, A., Dobson, C. A., & Vanicek, N. (2018). Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density. Gait and Posture, 64, 230-237. https://doi.org/10.1016/j.gaitpost.2018.05.005

Background: The gait patterns of women with low bone mineral density (BMD) or osteoporosis have not been thoroughly explored, and when examined, often studied in relation to falls and kyphosis. Research question: The aim of this study was to investig... Read More about Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density.