All Outputs (286)

Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity (2023)
Journal Article
Jamialahmadi, T., Bo, S., Abbasifard, M., Sathyapalan, T., Jangjoo, A., Moallem, S. A., Almahmeed, W., Ashari, S., Johnston, T. P., & Sahebkar, A. (2023). Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity. Journal of Health, Population and Nutrition, 42(1), Article 30. https://doi.org/10.1186/s41043-023-00372-8

BACKGROUND: Inflammation is critical in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). hs-CRP, an inflammatory marker, is considered one of the prognostic predictors of hepatic damage progression in NAFLD in some studies. METHODS: We... Read More about Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity.

Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit (2023)
Journal Article
Deshmukh, H., Adeleke, K. A., Ssemmondo, E., Wilmot, E. G., Shah, N., Pieri, B., Gregory, R., Kilvert, A., Lumb, A., Christian, P., Barnes, D., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2023). Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit. Diabetic medicine, 40(8), Article e15095. https://doi.org/10.1111/dme.15095

Metabolic and endocrine complications of long COVID-19: A review (2023)
Journal Article
Bandara, T., Deshmukh, H. A., Abdalla, M., & Sathyapalan, T. (2023). Metabolic and endocrine complications of long COVID-19: A review. Experimental and Clinical Endocrinology and Diabetes, 131(6), 367-374. https://doi.org/10.1055/a-2063-8697

Over the past two years, the COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), centralized the interest of the health care systems and the scientific world. Majority of the COVID-19 infected individuals fully r... Read More about Metabolic and endocrine complications of long COVID-19: A review.

Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu (2023)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Rizzo, M., & Sahebkar, A. (2024). Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu. Current medicinal chemistry, 31(2), 138-151. https://doi.org/10.2174/0929867330666230202163513

Patients with diabetes are at higher risk of cognitive impairment and memory loss than the normal population. Thus, using hypoglycemic agents to improve brain function is important for diabetic patients. Sodium-glucose cotransporters-2 inhibitors (S-... Read More about Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu.

HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study (2023)
Journal Article
Butler, A. E., Moin, A. S. M., Reiner, Ž., Sathyapalan, T., Jamialahmadi, T., Sahebkar, A., & Atkin, S. L. (2023). HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study. Cells, 12(6), https://doi.org/10.3390/cells12060855

INTRODUCTION: Serum lipoproteins, with the exception of high-density lipoprotein cholesterol (HDL-C), are increased in polycystic ovary syndrome (PCOS) and their levels may reflect the associated obesity and insulin resistance, but the nature of this... Read More about HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study.

The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit (2023)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Christian, P., Barnes, D. J., Walton, C., Ryder, R. E. J., & Sathyapalan, T. (2023). The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit. Diabetic medicine, 40(6), Article e15070. https://doi.org/10.1111/dme.15070

Aims: To investigate the change in glycated haemoglobin (HbA1c), hypoglycaemia awareness and diabetes-related distress in people with type 1 diabetes (T1D) using FreeStyle Libre (FSL) over a 2-year follow-up period. Methods: FSL user data from U.K wi... Read More about The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit.

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease (2023)
Journal Article
Sardou, H. S., Vosough, P. R., Abbaspour, M., Akhgari, A., Sathyapalan, T., & Sahebkar, A. (online). A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease. Inflammopharmacology, https://doi.org/10.1007/s10787-023-01140-0

Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse... Read More about A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease.

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons (2023)
Journal Article
Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (online). Modulatory properties of curcumin in cancer: A narrative review on the role of interferons. Phytotherapy Research, https://doi.org/10.1002/ptr.7734

The immune network is an effective network of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats and to prevent the risk of a wide range of diseases; hence, its proper functioning and balance are ess... Read More about Modulatory properties of curcumin in cancer: A narrative review on the role of interferons.

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies (2023)
Journal Article
Heidari, H., Bagherniya, M., Majeed, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (online). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy Research, https://doi.org/10.1002/ptr.7737

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioava... Read More about Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies.

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2022). Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D. Frontiers in endocrinology, 13, Article 935750. https://doi.org/10.3389/fendo.2022.935750

Introduction: Women with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been associated with vitamin D deficiency,... Read More about Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D.

Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery (2022)
Journal Article
Jangjoo, S., Emami, N., Sahranavard, M., Shah, N. Z., Alidadi, M., Baratzadeh, F., Sathyapalan, T., Eid, A. H., Jangjoo, A., Jamialahmadi, T., & Sahebkar, A. (2023). Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery. Obesity Surgery, 33, 548–554. https://doi.org/10.1007/s11695-022-06416-y

Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe obesity who were referred for... Read More about Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery.

Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial (2022)
Journal Article
Ajjan, R. A., Heller, S. R., Everett, C. C., Vargas-Palacios, A., Higham, R., Sharples, L., Gorog, D. A., Rogers, A., Reynolds, C., Fernandez, C., Rodrigues, P., Sathyapalan, T., Storey, R. F., & Stocken, D. D. (2023). Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial. Diabetes Care, 46(2), 441-449. https://doi.org/10.2337/dc22-1219

OBJECTIVE To analyze the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI) and assess cost effectiveness. RESEARCH DESIGN AND METHOD... Read More about Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial.

MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes (2022)
Journal Article
Ramanjaneya, M., Bettahi, I., Pawar, K., Halabi, N. M., Moin, A. S. M., Sathyapalan, T., Abou-Samra, A. B., Atkin, S. L., & Butler, A. E. (2022). MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes. International Journal of Molecular Sciences, 23(23), Article 14696. https://doi.org/10.3390/ijms232314696

Hypoglycemia, as a complication of type 2 diabetes (T2D), causes increased morbidity and mortality but the physiological response underlying hypoglycemia has not been fully elucidated. Small noncoding microRNA (miRNA) have multiple downstream biologi... Read More about MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes.

Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis (2022)
Journal Article
Deshmukh, H., Akbar, S., Bhaiji, A., Saeed, Y., Shah, N., Adeleke, K., Papageorgiou, M., Atkin, S., & Sathyapalan, T. (2023). Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis. Clinical Endocrinology, 98(3), 400-406. https://doi.org/10.1111/cen.14847

Introduction: Some but not all women with polycystic ovary syndrome (PCOS) develop the metabolic syndrome (MS). The objective of this study was to determine if a subset of women with PCOS had higher androgen levels predisposing them to MS and whether... Read More about Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis.

Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus (2022)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus. Current medicinal chemistry, 30(25), 2850-2863. https://doi.org/10.2174/0929867329666220831151645

Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and morbidity worldwide. It leads to various long-term complications such as diabetic nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with chro... Read More about Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus.

The Role of High-density Lipoprotein in Oral and Dental Diseases (2022)
Journal Article
Sadeghalbanaei, L., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2023). The Role of High-density Lipoprotein in Oral and Dental Diseases. Current medicinal chemistry, 30(20), 2226-2246. https://doi.org/10.2174/0929867329666220901120654

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, tr... Read More about The Role of High-density Lipoprotein in Oral and Dental Diseases.

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2022). Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Therapeutic Advances in Endocrinology and Metabolism, 13, https://doi.org/10.1177/20420188221127142

Context: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age, and metformin is a widely used medication in managing this condition. Aim: To review the available literature comprehensively o... Read More about Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians. Cardiovascular Diabetology, 21(1), Article 202. https://doi.org/10.1186/s12933-022-01639-w

Objective: Severe hypoglycemia is associated with increased cardiovascular death risk, and platelet responses to hypoglycemia (hypo) have been described. However, the impact of deep transient hypo (deep-hypo) versus prolonged milder hypo (mild-hypo)... Read More about The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians.

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome (2022)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2022). Components of the Complement Cascade Differ in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 23(20), Article 12232. https://doi.org/10.3390/ijms232012232

Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitor... Read More about Components of the Complement Cascade Differ in Polycystic Ovary Syndrome.

Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery (2022)
Journal Article
Ganjooei, N. A., Jamialahmadi, T., Nematy, M., Shah, N. Z., Jangjoo, S., Emami, N., Jangjoo, A., Faridnia, R., Alidadi, M., Sathyapalan, T., & Sahebkar, A. (2022). Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery. Middle East Journal of Digestive Diseases, 14(4), 410-421. https://doi.org/10.34172/mejdd.2022.302

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic fibrosis have emerged as one of the leading causes of chronic liver disease. The prevalence of the NAFLD spectrum has increased, which can be att... Read More about Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery.