All Outputs (38)

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells (2012)
Journal Article
Claessens, A., Adams, Y., Ghumra, A., Lindergard, G., Buchan, C. C., Andisi, C., …Rowe, J. A. (2012). A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 109(26), E1772-E1781. https://doi.org/10.1073/pnas.1120461109

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite a... Read More about A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium (2012)
Journal Article
Pakes, N. K., Veltman, D. M., Rivero, F., Nasir, J., Insall, R., & Williams, R. S. (2012). The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. Journal of cell science, 125(10), 2457-2465. https://doi.org/10.1242/jcs.100966

Dock (dedicator of cytokinesis) proteins represent a family of guanine nucleotide exchange factors (GEFs) that include the well-studied Dock180 family and the poorly characterised zizimin family. Our current understanding of Dock180 function is that... Read More about The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium.

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens (2012)
Journal Article
Caserta, S., Borger, J. G., & Zamoyska, R. (2012). Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical reviews in immunology, 32(2), 97-126. https://doi.org/10.1615/critrevimmunol.v32.i2.10

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolyti... Read More about Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

Direct processing of clinically relevant large volume samples for the detection of sexually transmitted infectious agents from urine on a microfluidic device (2012)
Journal Article
Kemp, C., Birch, C., Shaw, K. J., Nixon, G. J., Docker, P. T., Greenman, J., …Dyer, C. E. (2012). Direct processing of clinically relevant large volume samples for the detection of sexually transmitted infectious agents from urine on a microfluidic device. Analytical Methods, 4(7), 2141-2144. https://doi.org/10.1039/c2ay25075f

Urine is a preferred specimen for nucleic acid-based detection of sexually transmitted infections (STIs) but represents a challenge for microfluidic devices due to low analyte concentrations. We present an extraction methodology enabling rapid on-chi... Read More about Direct processing of clinically relevant large volume samples for the detection of sexually transmitted infectious agents from urine on a microfluidic device.

Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites (2012)
Journal Article
Oates, A., Bowling, F. L., Boulton, A. J. M., & McBain, A. J. (2012). Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites. Journal of clinical microbiology, 50(7), 2263-2271. https://doi.org/10.1128/JCM.06599-11

Wound debridement samples and contralateral (healthy) skin swabs acquired from 26 patients attending a specialist foot clinic were analyzed by differential isolation and eubacterium-specific PCR-denaturing gradient gel electrophoresis (DGGE) in conju... Read More about Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites.

Increased inducible heat shock protein 72 expression associated with PBMC isolated from patients with haematological tumours (2012)
Journal Article
Madden, L. A., Hayman, Y. A., Underwood, C., Vince, R. V., Greenman, J., Allsup, D., & Ali, S. (2012). Increased inducible heat shock protein 72 expression associated with PBMC isolated from patients with haematological tumours. Scandinavian journal of clinical & laboratory investigation, 72(5), 380-386. https://doi.org/10.3109/00365513.2012.681683

Background. Heat shock protein 72 (Hsp72) is a highly inducible stress protein and molecular chaperone. Cancers have been shown to be associated with increased Hsp72 expression within the tumour itself and this may lead to resistance to apoptosis. Me... Read More about Increased inducible heat shock protein 72 expression associated with PBMC isolated from patients with haematological tumours.

Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms (2012)
Journal Article
Abdul Rahman, M., Mazari, F., Khan, J. A., Madden, L., McCollum, P., Shahin, Y., …Smith, G. (2012). Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms. Annals of vascular surgery, 26(3), 322-329. https://doi.org/10.1016/j.avsg.2011.08.015

BACKGROUND The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix... Read More about Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms.

Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy (2012)
Journal Article
Anbalagan, S., Monteiro dos Santos Pires, I., Blick, C., Hill, M. A., Ferguson, D. J. P., Chan, D. A., & Hammond, E. M. (2012). Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 103(3), 388-393. https://doi.org/10.1016/j.radonc.2012.04.001

Background and purpose: For patients diagnosed with advanced renal cell carcinoma (RCC), there are few therapeutic options. Radiation therapy is predominantly used to treat metastasis and has not proven effective in the adjuvant setting for renal can... Read More about Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy.

Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma (2012)
Journal Article
Matsakas, A., Yadav, V., Lorca, S., Evans, R., & Narkar, V. (2012). Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma. Circulation Research, 110(8), 1087-1096. https://doi.org/10.1161/CIRCRESAHA.112.266478

RATIONALE Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during ischemia. Estrogen-related receptor-gamma (ERRγ) activates genes that govern metabolic and vasc... Read More about Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma.

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells (2012)
Journal Article
Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A. S., …Zamoyska, R. (2012). Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE, 7(4), e35466. https://doi.org/10.1371/journal.pone.0035466

Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibito... Read More about Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites (2012)
Journal Article
Ghumra, A., Semblat, J. P., Ataide, R., Kifude, C., Adams, Y., Claessens, A., …Rowe, J. A. (2012). Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites. PLoS Pathogens, 8(4), Article e1002665. https://doi.org/10.1371/journal.ppat.1002665

Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion m... Read More about Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites.

Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells (2012)
Journal Article
Ramasamy, K., Khatun, H., Macpherson, L., Caley, M. P., Sturge, J., Mufti, G. J., …Calle, Y. (2012). Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells. British journal of haematology, 157(5), 564-579. https://doi.org/10.1111/j.1365-2141.2012.09103.x

The response of the tumour microenvironment to anti-cancer drugs can influence treatment efficacy. Current drug-screening methodologies fail to distinguish and quantify simultaneously the concomitant effect of drugs on the tumour stroma and cancer ce... Read More about Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells.

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection (2012)
Journal Article
Nunes, J., Naymark, M., Sauer, L., Muhammad, A., Keun, H., Sturge, J., …Pchejetski, D. (2012). Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. The British Journal of Cancer, 106(5), 909-915. https://doi.org/10.1038/bjc.2012.14

Background: Current markers available for screening normal populations and for monitoring prostate cancer (PCa) treatment lack sensitivity and selectivity. Sphingosine-1-phosphate (S1P) is a circulating lipid second messenger involved in cell growth... Read More about Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.

Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications (2012)
Journal Article
Cheah, L. T., Fritsch, I., Haswell, S. J., & Greenman, J. (2012). Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications. Biotechnology and bioengineering, 109(7), 1827-1834. https://doi.org/10.1002/bit.24426

A microfluidic system containing a chamber for heart tissue biopsies, perfused with Krebs–Henseleit buffer containing glucose and antibiotic (KHGB) using peristaltic pumps and continuously stimulated, was used to evaluate tissue viability under redox... Read More about Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications.

Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels (2012)
Journal Article
Jiang, H., Zeng, B., Chen, G., Bot, D., Eastmond, S., Elsenussi, S. E., …Xu, S. (2012). Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels. Biochemical Pharmacology, 83(7), 923-931. https://doi.org/10.1016/j.bcp.2012.01.014

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used anti-inflammatory therapeutic agents,among which the fenamate analogues play important roles in regulating intracellular Ca2+ transient and ion channels. However, the effect of NSAIDs on... Read More about Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels.

Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts (2012)
Journal Article
Sadofsky, L. R., Ramachandran, R., Crow, C., Cowen, M., Compton, S. J., & Morice, A. H. (2012). Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Experimental Lung Research, 38(2), 75-81. https://doi.org/10.3109/01902148.2011.644027

Lung fibroblasts are involved in interstitial lung disease, chronic asthma, and chronic obstructive pulmonary disease (COPD). The expanded fibroblast population in airway disease leads to airway remodeling and contributes to the inflammatory process... Read More about Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts.

Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells (2012)
Journal Article
Sultana, H., Neelakanta, G., Rivero, F., Blau-Wasser, R., Schleicher, M., & Noegel, A. A. (2012). Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells. BMC developmental biology, 12, Article 3. https://doi.org/10.1186/1471-213X-12-3

Background: Cell adhesion, an integral part of D. discoideum development, is important for morphogenesis and regulated gene expression in the multicellular context and is required to trigger cell-differentiation. G-protein linked adenylyl cyclase pat... Read More about Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells.

Voltammetric Immunoassay for the Detection of Protein Biomarkers (2012)
Journal Article
Haswell, S. J., Dou, Y., Wadhawan, J., & Greenman, J. (2012). Voltammetric Immunoassay for the Detection of Protein Biomarkers. Electroanalysis, 24(2), 264-272. https://doi.org/10.1002/elan.201100676

A strategy for a fast (ca. 20 min), specific, electrochemical immunoassay for the cardiac biomarker creatine kinase (CK) and the human cytokine interleukin 10 (IL10) has been developed in this paper. The polyaniline modified gold surface formed from... Read More about Voltammetric Immunoassay for the Detection of Protein Biomarkers.