All Outputs (35)

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., Greetham, S., Doyle, B., Hayes, N., Rigby, A., Atkin, S. L., Courts, F. L., & Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes. Life Sciences, 241, Article 117152. https://doi.org/10.1016/j.lfs.2019.117152

GLP-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) are two classes of antidiabetic agents used in the management of diabetes based on incretin hormones. There is emerging evidence that they have anti-inflammatory effects... Read More about Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes.

Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., Maleki, M., Jamialahmadi, T., & Sahebkar, A. (2020). Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review. Life Sciences, 240, Article 117090. https://doi.org/10.1016/j.lfs.2019.117090

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are a relatively newer class of anti-hyperglycemic medications that reduce blood glucose by inhibition of renal glucose re-uptake, thereby increasing urinary glucose excretion. Although glycosuria i... Read More about Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review.

Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet (2019)
Journal Article
Ganie, M. A., Sahar, T., Rashid, A., Wani, I. A., Nisar, S., Sathyapalan, T., Vishnubhatla, S., Ramakrishnan, L., Parvez, T., & Geer, I. (2019). Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet. Frontiers in endocrinology, 10, Article 699. https://doi.org/10.3389/fendo.2019.00699

Background: Sub-inflammation and insulin resistance characterize women with PCOS. Data on dietary modulation of inflammation among PCOS women is scant, particularly from Indian subcontinent. The present study aimed to assess the effect of plant based... Read More about Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet.

Expression of microRNA in follicular fluid in women with and without PCOS (2019)
Journal Article
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., Sathyapalan, T., Najafi-Shoushtari, S. H., & Atkin, S. L. (2019). Expression of microRNA in follicular fluid in women with and without PCOS. Scientific reports, 9(1), Article 16306. https://doi.org/10.1038/s41598-019-52856-5

© 2019, The Author(s). Several studies have shown the expression of small non-coding microRNA (miRNA) changes in PCOS and their expression in follicular fluid has been described, though the number of studies remains small. In this prospective cohort... Read More about Expression of microRNA in follicular fluid in women with and without PCOS.

The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms (2019)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., & Sahebkar, A. (2019). The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sciences, 237, Article 116950. https://doi.org/10.1016/j.lfs.2019.116950

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstr... Read More about The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms.

Effects of curcumin on mitochondria in neurodegenerative diseases (2019)
Journal Article
Bagheri, H., Ghasemi, F., Barreto, G. E., Rafiee, R., Sathyapalan, T., & Sahebkar, A. (2020). Effects of curcumin on mitochondria in neurodegenerative diseases. BioFactors, 46(1), 5-20. https://doi.org/10.1002/biof.1566

Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., p... Read More about Effects of curcumin on mitochondria in neurodegenerative diseases.

Anti-fibrotic effects of curcumin and some of its analogues in the heart (2019)
Journal Article
Gorabi, A. M., Hajighasemi, S., Kiaie, N., Rosano, G. M. C., Sathyapalan, T., Al-Rasadi, K., & Sahebkar, A. (2020). Anti-fibrotic effects of curcumin and some of its analogues in the heart. Heart Failure Reviews, 25(5), 731-743. https://doi.org/10.1007/s10741-019-09854-6

Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, wh... Read More about Anti-fibrotic effects of curcumin and some of its analogues in the heart.

Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome (2019)
Journal Article
Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., Suhre, K., Sathyapalan, T., & Atkin, S. L. (2019). Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome. Clinical Endocrinology, 91(6), 793-797. https://doi.org/10.1111/cen.14087

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women or... Read More about Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Therapeutic effects of Crocin in autoimmune diseases: A review (2019)
Journal Article
Korani, S., Korani, M., Sathyapalan, T., & Sahebkar, A. (2019). Therapeutic effects of Crocin in autoimmune diseases: A review. BioFactors, 45(6), 835-843. https://doi.org/10.1002/biof.1557

The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple... Read More about Therapeutic effects of Crocin in autoimmune diseases: A review.

A review of the pharmacological and therapeutic effects of auraptene (2019)
Journal Article
Bibak, B., Shakeri, F., Barreto, G. E., Keshavarzi, Z., Sathyapalan, T., & Sahebkar, A. (2019). A review of the pharmacological and therapeutic effects of auraptene. BioFactors, 45(6), 867-879. https://doi.org/10.1002/biof.1550

There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the th... Read More about A review of the pharmacological and therapeutic effects of auraptene.

Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity (2019)
Journal Article
Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life Sciences, 234, Article 116776. https://doi.org/10.1016/j.lfs.2019.116776

Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptid... Read More about Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity.

Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom (2019)
Journal Article
Drage, D. S., Heffernan, A. L., Cunningham, T. K., Aylward, L. L., Mueller, J. F., Sathyapalan, T., & Atkin, S. L. (2019). Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom. Environmental Research, 177, Article 108631. https://doi.org/10.1016/j.envres.2019.108631

We investigated the serum concentrations of two brominated flame retardants (BFRs) – polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD) –in 59 women aged between 23 and 42 from the United Kingdom. We also collected demographic... Read More about Serum measures of hexabromocyclododecane (HBCDD) and polyborminated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom.

Is weight loss harmful for skeletal health in obese older adults? (2019)
Journal Article
Papageorgiou, M., Kerschan-Schindl, K., Sathyapalan, T., & Pietschmann, P. (2020). Is weight loss harmful for skeletal health in obese older adults?. Gerontology, 66(1), 2-14. https://doi.org/10.1159/000500779

Purpose of Review: In view of the existing uncertainty about the implications of intentional weight loss in older obese adults, the present review (a) summarizes the available evidence from epidemiological and interventional studies concerning the ef... Read More about Is weight loss harmful for skeletal health in obese older adults?.

The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., Smith, A., Cianflone, K., & Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394

Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited (2019)
Journal Article
Keshavarzi, Z., Shakeri, F., Barreto, G. E., Bibak, B., Sathyapalan, T., & Sahebkar, A. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. BioFactors, 45(4), 517-535. https://doi.org/10.1002/biof.1516

Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI... Read More about Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited.

Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial (2019)
Journal Article
Mosenzon, O., Blicher, T. M., Rosenlund, S., Eriksson, J., Heller, S., Hels, O. H., Pratley, R., Sathyapalan, T., Desouza, C., Abramof, R., Alpenidze, D., Aronoff, S., Astamirova, K., Barker, B., Bedel, G., Belousova, L., Benson, M., Beshay, I., Biggs, W., Blaze, K., …Zhdanova, E. (2019). Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes and Endocrinology, 7(7), 515-527. https://doi.org/10.1016/S2213-8587%2819%2930192-5

Background: Oral semaglutide is the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for glycaemic control in patients with type 2 diabetes. Type 2 diabetes is commonly associated with renal impairment, restricting treatment options. We ai... Read More about Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial.

Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage (2019)
Journal Article
Sathyapalan, T., Yaribeygi, H., Sahebkar, A., & Lhaf, F. (2019). Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage. Life Sciences, 231, Article 116538. https://doi.org/10.1016/j.lfs.2019.06.013

Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular me... Read More about Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage.

Curcumin: a modulator of inflammatory signaling pathways in the immune system (2019)
Journal Article
Kahkhaie, K. R., Mirhosseini, A., Aliabadi, A., Mohammadi, A., Mousavi, M. J., Haftcheshmeh, S. M., Sathyapalan, T., & Sahebkar, A. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 27(5), 885-900. https://doi.org/10.1007/s10787-019-00607-3

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflamma... Read More about Curcumin: a modulator of inflammatory signaling pathways in the immune system.